Structure of Beta AmyloidPeptide1 42CAS 107761 42 2 449x400 - Beta-AmyloidPeptide(1-42),CAS 107761-42-2

custom peptides - Beta-AmyloidPeptide(1-42),CAS 107761-42-2

Iden­ti­fi­ca­tion

CAS Number

107761-42-2

Name

Beta-AmyloidPeptide(1-42)

Pep­tide sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Syn­onyms

107761-42-2 [RN]
Human β-amy­loid pep­tide (1-42)
β-amy­loid 42
β-amy­loid polypep­tide 42
β-amy­loid pro­tein 42
??-Amyloid(1-42) Human
[107761-42-2]
Amy­loid β-Pep­tide (1-42) (human)
amy­loid-β polypep­tide 42
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
DAE­FRHDS­GYEVH­HQK­LVF­FAED­VGSNKGAI­IGLMVG­GVVIA
https://​www​.ebi​.ac​.uk/​c​h​e​b​i​/​s​e​a​r​c​h​I​d​.​d​o​?​c​h​e​b​i​I​d​=​C​H​E​B​I​:​6​4​647
L-α-aspartyl-L-alanyl-L-α-glu­­tamyl-L-pheny­lalanyl-L-arginyl-L-his­tidyl-L-α-aspartyl-L-seryl­g­ly­­cyl-L-tyro­­syl-L-α-glu­­tamyl-L-valyl-L-his­tidyl-L-his­tidyl-L-glu­t­a­minyl-L-lysyl-L-leucyl-L-valyl-L-pheny­lalanyl-L-pheny­lalanyl-L-alanyl-L-α-glu­­tamyl-L-α-aspartyl-L-valyl­g­ly­­cyl-L-seryl-L-asparaginyl-L-lysyl­g­ly­­cyl-L-alanyl-L-isoleucyl-L-isoleucyl­g­ly­­cyl-L-leucyl-L-methionyl-L-valyl­g­ly­­cyl­g­ly­­cyl-L-valyl-L-valyl-L-isoleucyl-L-ala­­nine
MFCD01864012
Not avail­able
β-amyloid(1-42) human

SMILES

[H]/N=C(\N)/NCCC[C@@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC­CN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC­CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](Cc7ccccc7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N

Std­InChI

InChI=1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112(26)202(317)318)257-201(316)166(108(22)30-3)256-169(284)109(23)224-147(265)89-216-171(286)122(51-40-42-67-204)233-188(303)139(81-145(208)263)244-192(307)143(94-260)230-150(268)92-219-194(309)159(101(10)11)252-191(306)141(83-157(280)281)245-177(292)127(60-64-153(272)273)232-168(283)111(25)226-180(295)133(73-113-45-34-31-35-46-113)241-184(299)135(75-115-49-38-33-39-50-115)247-196(311)162(104(16)17)254-190(305)131(72-99(6)7)239-173(288)123(52-41-43-68-205)234-175(290)125(58-62-144(207)262)236-185(300)136(77-117-84-211-95-221-117)243-187(302)138(79-119-86-213-97-223-119)248-197(312)161(103(14)15)253-178(293)128(61-65-154(274)275)237-182(297)132(76-116-54-56-120(261)57-55-116)229-148(266)90-217-172(287)142(93-259)249-189(304)140(82-156(278)279)246-186(301)137(78-118-85-212-96-222-118)242-174(289)124(53-44-69-214-203(209)210)235-183(298)134(74-114-47-36-32-37-48-114)240-176(291)126(59-63-152(270)271)231-167(282)110(24)225-170(285)121(206)80-155(276)277/h31-39,45-50,54-57,84-86,95-112,121-143,158-166,259-261H,28-30,40-44,51-53,58-83,87-94,204-206H2,1-27H3,(H2,207,262)(H2,208,263)(H,211,221)(H,212,222)(H,213,223)(H,215,264)(H,216,286)(H,217,287)(H,218,308)(H,219,309)(H,220,310)(H,224,265)(H,225,285)(H,226,295)(H,227,315)(H,228,267)(H,229,266)(H,230,268)(H,231,282)(H,232,283)(H,233,303)(H,234,290)(H,235,298)(H,236,300)(H,237,297)(H,238,296)(H,239,288)(H,240,291)(H,241,299)(H,242,289)(H,243,302)(H,244,307)(H,245,292)(H,246,301)(H,247,311)(H,248,312)(H,249,304)(H,250,269)(H,251,294)(H,252,306)(H,253,293)(H,254,305)(H,255,313)(H,256,284)(H,257,316)(H,258,314)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,317,318)(H4,209,210,214)/t106-,107-,108-,109-,110-,111-,112-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,158-,159-,160-,161-,162-,163-,164-,165-,166-/m0/s1

Std­InChIKey

DZH­SAH­HDTR­WUTF-SIQRNX­­PUSA-N

Mol­e­c­u­lar Formula

C203H311N55O60S

Mol­e­c­u­lar Weight

4514.04

MDL Number

MFCD00163049

Prop­er­ties

Appear­ance

White pow­der

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Beta-AmyloidPeptide(1-42),CAS 107761-42-2

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

98% min

Absorp­tion coefficient

1280 M-1cm-1 

PI,iso­elec­tric point

pH 5.17 

Net charge at pH 7

-2.7 

Sol­u­bil­i­ty evaluation

Poor water solubility

Tox­i­c­i­ty mech­a­nism of Amy­loid oligomer

  1. The effect on oxida­tive stress. Aβ can induce oxida­tive stress, pro­duce a large num­ber of free rad­i­cals, and then pro­duce oxida­tive stress on neurons.
  2. Cause Ca2+ dis­or­der. Aβ destroys the K+ chan­nel on the cell mem­brane, caus­ing a large amount of Ca2+ influx.
  3. Inter­ac­tion with recep­tors on the cell mem­brane sur­face. Amy­loid oligomers can acti­vate exci­ta­to­ry NMDA2RS recep­tors, caus­ing mito­chon­dr­i­al dis­or­ders and neu­ronal death.
  4. Amy­loid in cells is also an impor­tant patho­log­i­cal fea­ture. A large num­ber of oligomers in the cells cause pathol­o­gy. The pro­duc­tion and degra­da­tion of Amy­loid secret­ed by nor­mal cells is rel­a­tive­ly balanced.
  5. Break the bal­ance between Bax and Bel-2.

Shelf Life

2 years

Stor­age

Store at -20°C or -80°C for long time, Sealed and away from light

Known Appli­ca­tion

Often used to study Alzheimer’s disease.

This prod­uct is devel­oped by our R&D com­pa­ny Apnoke Sci­en­tif­ic Ltd (http://​www​.apnoke​.com/), and here is the cor­re­spond­ing link http://​www​.apnoke​.com/​b​e​t​a​-​a​m​y​l​o​i​d​p​e​p​t​i​d​e​1​-​4​2​c​a​s​-​1​0​7​7​6​1​-​4​2​-2/

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