Halofug­i­non Lac­tate CAS 82186-71-8

Iden­ti­fi­ca­tion
Prop­er­ties
Safe­ty Data
Spec­i­fi­ca­tions and Oth­er Infor­ma­tion
Links

Iden­ti­fi­ca­tion

CAS Number

82186-71-8

Name

Halofug­i­non Lactate

Syn­onyms

2-Hydrox­­ypropanoic acid – 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quina­zoli­none (1:1) [ACD/IUPAC Name]
2-Hydrox­­ypropan­säure –7-brom-6-chlor-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-chi­na­zoli­non (1:1) [Ger­man] [ACD/IUPAC Name]
Acide 2-hydrox­­ypropanoïque – 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-pipéridinyl]-2-oxopropyl}-4(3H)-quina­zoli­none (1:1) [French] [ACD/IUPAC Name]
Propanoic acid, 2-hydroxy-, com­pd. with 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quina­zoli­none (1:1) [ACD/​Index Name]
2-Hydrox­­ypropanoic acid [ACD/IUPAC Name]
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one;2-hydroxypropanoic acid
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one and 2-hydrox­­ypropanoic acid
82186-71-8 [RN]
Halofug­i­none lac­tate
Halofug­i­none lac­tate 100 ?g/​mL in Ace­toni­trile
Halofug­i­none lac­tate 100 µg/​mL in Ace­toni­trile – short expiry, for imme­di­ate use only

SMILES

CC(C(=O)O)O.c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)C[C@H]3[C@@H](CCCN3)O

Std­InChI

InChI=1S/​C16H17BrClN3O3.C3H6O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;1-2(4)3(5)6/h5-6,8,14-15,19,23H,1-4,7H2;2,4H,1H3,(H,5,6)/t14-,15+;/m0./s1

Std­InChIKey

GATQERN­JKZPJNX-LDXVYITE­SA-N

Mol­e­c­u­lar Formula

C19H23BrClN3O6

Mol­e­c­u­lar Weight

504.76

Prop­er­ties

Appear­ance

Off-white to white solid

Safe­ty Data

WGK Germany

3

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Halofug­i­non Lac­tate CAS 82186-71-8

Stan­dard

Enter­prise standard

Iden­ti­fi­ca­tion Methods

HPLC/HNMR

Puri­ty

97%min

Relat­ed substances

cis-Halofug­i­none Lactate

≤2.0%

Total inpu­ri­ties

≤3.0%

Loss on drying

≤1.0%

Shelf life

2 years

Pack­age

Accord­ing to cus­tomer require­ments to packaging

Stor­age

Store in a cool and dry place.

Appli­ca­tion

Halofug­i­none is a coc­cidio­stat used in vet­eri­nary med­i­cine. It is a syn­thet­ic halo­genat­ed deriv­a­tive of febrifug­ine, a nat­ur­al quina­zoli­none alka­loid which can be found in the Chi­nese herb Dichroa febrifu­ga (Chang Shan).Collgard Bio­phar­ma­ceu­ti­cals is devel­op­ing halofug­i­none for the treat­ment of scle­ro­der­ma and it has received orphan drug des­ig­na­tion from the U.S. Food and Drug Admin­is­tra­tion.
Halofug­i­none inhibits the devel­op­ment of T helper 17 cells, immune cells that play an impor­tant role in autoim­mune dis­ease, but it does not affect oth­er kinds of T cells which are involved in nor­mal immune function.Halofuginone there­fore has poten­tial for the treat­ment of autoim­mune dis­or­ders.
Halofug­i­none is also an inhibitor of col­la­gen type I gene expres­sion and as a con­se­quence it may inhib­it tumor cell growth.Halofuginone exerts its effects by act­ing as a high affin­i­ty inhibitor of the enzyme Glu­­tamyl-Pro­­lyl tRNA syn­thetase. Inhi­bi­tion of pro­lyl tRNA charg­ing leads to the accu­mu­la­tion of uncharged pro­lyl tRNAs, which serve as a sig­nal to ini­ti­ate the amino acid star­va­tion response, which in turn exerts anti-inflam­­ma­­to­ry and anti-fibrot­ic effects.

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our RandD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​h​a​l​o​f​u​g​i​n​o​n​-​l​a​c​t​a​t​e​-​c​a​s​-​8​2​1​8​6​-​7​1​-8/

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andD pur­pose. It may be tox­ic or haz­ardous, and should be han­dled only by qual­i­fied indi­vid­u­als trained in lab­o­ra­to­ry pro­ce­dures. The buy­er will be respon­si­ble to warn and inform any per­son that may be in con­tact with the prod­uct of the poten­tial risks and haz­ards, as well as to ensure that pur­chase, use and dis­pos­al of the prod­uct com­ply with local laws and regulations.