Structure of Nalfurafine hydrochloride CAS 152658 17 8 - Nalfurafine hydrochloride CAS 152658-17-8 Iden­ti­fi­ca­tion Prop­er­ties Safe­ty Data Spec­i­fi­ca­tions and Oth­er Information Links

Iden­ti­fi­ca­tion

CAS Number

152658-17-8

Name

Nal­fu­rafine hydrochlo­ride

Syn­onyms

(2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]-3-(3-furyl)-N-methylacrylamide hydrochlo­ride (1:1) [ACD/IUPAC Name] (2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]-3-(3-furyl)-N-methylacrylamidhydrochlorid (1:1) [Ger­man] [ACD/IUPAC Name] (2E)-N-[(5α,6β)-17-(Cyclopropylméthyl)-3,14-dihydroxy-4,5-époxymorphinane-6-yl]-3-(3-furyl)-N-méthylacrylamide, chlorhy­drate (1:1) [French] [ACD/IUPAC Name] 152658-17-8 [RN] 2-Prope­­namide, N-[(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, (2E)-, hydrochlo­ride (1:1) [ACD/​Index Name] Nal­fu­rafine hydrochlo­ride [USAN] Nal­fu­rafine (hydrochlo­ride) Remitch hydrochlo­ride TRK-820 hydrochlo­ride UNII-25C­C4N0P8J

Mol­e­c­u­lar Structure

Structure of Nalfurafine hydrochloride CAS 152658 17 8 - Nalfurafine hydrochloride CAS 152658-17-8

Struc­ture of Nal­fu­rafine hydrochlo­ride CAS 152658-17-8

SMILES

CN([C@@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)/C=C/C7=COC=C7.Cl

Std­InChI

InChI=1S/C28H32N2O5.ClH/c1-29(23(32)7-4-18-9-13-34-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)35-25)11-12-30(22)15-17-2-3-17;/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3 ;1H/b7-4+;/t20-,22-,26+,27+,28-;/m1./s1

Std­InChIKey

DJS­­FYNINGIMK­AG-FQJQBBMWSA-N

Mol­e­c­u­lar Formula

C28H33ClN2O5

Mol­e­c­u­lar Weight

513.025

Prop­er­ties

Appear­ance

White pow­der

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Nal­fu­rafine hydrochlo­ride CAS 152658-17-8

Stan­dard

Enter­prise stan­dard

Iden­ti­fi­ca­tion Methods

HNMR/HPLC

Puri­ty

98%min

Heavy Met­al

10ppm

Stor­age

Under the room tem­per­a­ture and away from light

Appli­ca­tion

Nal­fu­rafine hydrochlo­ride was launched on March of 2009 in Japan as the first in class non-nar­­cot­ic opi­oid drug for intractable itch caused by hemodial­y­sis. It showed sig­nif­i­cant opi­oid ago­nist acti vity and induced nei­ther aver­sion nor pref­er­ence in rats on the CPP (Con­di­tioned Place Pref­er­ence) test. A new ther­a­peu­tic agent for the treat­ment of ure­mic pru­ri­tus in hemodial­y­sis patients.

Links

This prod­uct is devel­oped by our RandD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​n​a​l​f​u​r​a​f​i​n​e​-​h​y​d​r​o​c​h​l​o​r​i​d​e​-​c​a​s​-​1​5​2​6​5​8​-​1​7​-8/

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