Tetra­cos­ac­tide Acetate CAS 16960-16-0

Iden­ti­fi­ca­tion Prop­er­ties Safe­ty Data Spec­i­fi­ca­tions & Oth­er Information Links

Iden­ti­fi­ca­tion

CAS Number

16960-16-0

Name

Tetra­cos­ac­tide Acetate

Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe- Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys- Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr- Pro

Syn­onyms

16960-16-0 [RN] Cortrosyn [Trade name] cosyn­tropin [USAN] L-Pro­­line, L-seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-v alyl-L-lysyl-L-valyl-L-tyro­­syl- [ACD/​Index Name] L-pro­­line, L-seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysyl-L-valyl-L-tyro­­syl- L-seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysy L-Seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysy l-L-valyl-L-tyro­­syl-L-pro­lin [Ger­man] [ACD/IUPAC Name] L-Seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysy l-L-valyl-L-tyro­­syl-L-pro­­line [ACD/IUPAC Name] L-Séryl-L-tyro­­syl-L-séryl-L-méthionyl-L-α-glu­­tamyl-L-his­tidyl-L-phény­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysy l-L-valyl-L-tyro­­syl-L-pro­­line [French] [ACD/IUPAC Name] L-Seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysyl-L-valyl-L-tyro­­syl-L-pro­­line Porcine ACTH (1-24) tetra­cos­ac­ti­da [Span­ish] [INN] Tetra­cos­ac­tide [INN] [Wiki] tétra­cos­ac­tide [French] [INN] tetra­cos­ac­tidum [Latin] [INN] y-29-(4-hydroxybenzyl)-26-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-8-(1H-indol-3-ylmethyl)-23-[2-(methylsulfanyl)ethyl]-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritria α1-24-Cor­ti­­cotropin тетракозактид [Russ­ian] [INN] تيتراكوساكتيد [Ara­bic] [INN] 替可克肽 [Chi­nese] [INN] ??1-24-cor­ti­­cotrophin [16960-16-0] a1-24-Cor­ti­­cotropin ACTH (1-24) (human, bovine, rat) ACTH (1-24), Human ACTH(1-24) Actho­lain Adreno­cor­ti­cotrop­ic hor­mone 1-24 Adreno­cor­ti­cotrop­ic hor­mone frag­ment 1-24 human, rat ATCH (1-24) Cor­ti­cotropin tetra­cos­apep­tide Corticotropin-(1-24) corticotropin-(1-24) tetra­cos­apep­tide Cortrophin S L-seryl-L-tyro­­syl-L-seryl-L-methionyl-L-α-glu­­tamyl-L-his­tidyl-L-pheny­lalanyl-L-arginyl-L-tryp­­to­­phyl­g­ly­­cyl-L-lysyl-L-pro­­lyl-L-valyl­g­ly­­cyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-pro­­lyl-L-valyl-L-lysyl-L-valyl-L-tyro­­syl-L-pro­­ly­­line MFCD00167476 [MDL num­ber] Ser­TyrSer­Met­GluHisP­heArgTrpG­lyLysProVal­GlyLysLysAr­gArg­ProValLysVal­Tyr­Pro Syn­ac­thene-retard SYS­ME­HFR­WGKPVGKKR­RPVKVYP Tetra­cos­ac­tid tetra­cos­ac­trin Tetra­cos­apep­tide α(1-24)-corticotrophin β(1-24)-corticotrophin

SMILES

CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCC­CN)C(=O)N[C@@H](CCC­CN)C(=O)N[C@@H](CCC­NC(=N)N)C(=O)N[C@@H](CCC­NC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC­CN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCC­CN)NC(=O)CNC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCC­NC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC8=CN=CN8)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CC=C(C=C9)O)NC(=O)[C@H](CO)N

Std­InChI

InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1

Std­InChIKey

ZOE­FC­CM­­DU­URGSE-SQKVD­D­B­VSA-N

Mol­e­c­u­lar Formula

C136H210N40O31S

Mol­e­c­u­lar Weight

2933.5

EINECS

241-031-1

MDL Number

MFCD00167476

Prop­er­ties

Appear­ance

White or yel­low, amor­phours pow­der

Safe­ty Data

RIDADR

NONH for all modes of trans­port

WGK Germany

3 

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Tetra­cos­ac­tide Acetate CAS 16960-16-0

Stan­dard

Enter­prise stan­dard

Iden­ti­fi­ca­tion Methods

HPLC

Assay(anhydrous and acetic acid –free substance)

90～102%

Iden­ti­ty by Amino Acids Analysis

Lys : 3.5~4.7 His:0.9~1.1 Arg : 2.7~3.3 Ser:1.1~2.2 Glu : 0.9~1.1 Pro : 2.5~3.5 Gly : 1.8~2.2 Met : 0.9~1.1 Tyr : 1.7~2.2 Phe:0.9~1.1

Spe­cif­ic Opti­cal Rotation

-99.0～-109.0°(c=1，1%HAc)

Absorbance(0.2mg/ml 0.1M HCl)

Amax 276nm 0.51~0.61

Relat­ed Substance(By HPLC)

Total Impurities(%):≤9.0% Any Sin­gle Impurity(%):≤2.5%

Acetate Con­tent (By HPLC)

8.0~13.0%

Water Content(Karl Fischer)

≤14.0%

Bac­te­r­i­al Endotoxins

≤10IU/​mg

Pack­age

Accord­ing to cus­tomer require­ments to pack­ag­ing

Stor­age

Store at 2-8℃，,Sealed and away from light

Appli­ca­tion

For the diag­no­sis of adren­al insuf­fi­cien­cy ; also for the treat­ment of rheuma­tism, rheuma­toid arthri­tis, skin dis­eases and shock.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Apnoke Sci­en­tif­ic Ltd(http://​www​.apnoke​.com/), and here is the cor­re­spond­ing linkhttp://​www​.apnoke​.com/​t​e​t​r​a​c​o​s​a​c​t​i​d​e​-​a​c​e​t​a​t​e​-​c​a​s​-​1​6​9​6​0​-​1​6​-0/

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