11A-HYDROXY-18-METHYL-ESTR-4-ENE-3,17-DIONE CAS 53067-82-6

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• Prop­er­ties
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Iden­ti­fi­ca­tion

CAS Number

53067-82-6

Name

11A-HYDROXY-18-METHYL-ESTR-4-ENE-3,17-DIONE

Syn­onyms

Val­i­dat­ed by Experts, Val­i­dat­ed by Users, Non-Val­i­­dat­ed, Removed by Users
(8S,9S,10R,11R,13S,14S)-13-Ethyl-11-hydroxy-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3,17(2H,6H)-dion [Ger­man] [ACD/IUPAC Name]
(8S,9S,10R,11R,13S,14S)-13-Ethyl-11-hydroxy-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione [ACD/IUPAC Name]
(8S,9S,10R,11R,13S,14S)-13-Éthyl-11-hydroxy-7,8,9,10,11,12,13,14,15,16-décahydro-1H-cyclopenta[a]phénanthrène-3,17(2H,6H)-dione [French] [ACD/IUPAC Name]
53067-82-6 [RN]
(8S,9S,10R,11R,13S,14S)-13-ethyl-11-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione
(8S,9S,10R,11R,13S,14S)-13-ethyl-11-hydroxy-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione
(8S,9S,11R,13S,14S)-13-Ethyl-11-hydroxy-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione (non-pre­­ferred name)
11??-hydroxy-13-ethyl-gon-4-ene-3,17-dione
11a-Hydroxy-18-methylestr-4-ene-3,17-dione
11A-Hydroxy-18-methyl-estr-4-ene-3,17-dione
MFCD22200579 [MDL number]

SMILES

CC[C@]12C[C@H]([C@H]3[C@H]([C@@H]1CCC2=O)CCC4=CC(=O)CC[C@H]34)O

Std­InChI

InChI=1S/C19H26O3/c1-2-19-10-16(21)18-13-6-4-12(20)9-11(13)3-5-14(18)15(19)7-8-17(19)22/h9,13-16,18,21H,2-8,10H2,1H3/t13-,14-,15-,16+,18+,19-/m0/s1

Std­InChIKey

JEMKJBGEAVUIOC-ZRTW­PRGN­SA-N

Mol­e­c­u­lar Formula

C₁₉H₂₆O₃

Mol­e­c­u­lar Weight

302.408

Prop­er­ties

Appear­ance

Off-white crys­talline powder

Melt­ing Point

1ss~19s ℃

struc­ture

struc­ture of 11A-HYDROXY-18-METHYL-ESTR-4-ENE-3,17-DIONE CAS 53067-82-6

Safe­ty Data

WGK Germany

3

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Assay

90% min

Spe­cif­ic Opti­cal Rotation

-10~-18° (Diox­ane)

-3~-13° (Chlo­ro­form)

Water

≤0.5%

Loss on Drying

≤0.5%

11 a- Hydroxy -18-methyl-estr-4-ene- 3-one-1713 -ol 

≤1.0%

15a-Hydroxy-18-methyl-estra-4-ene-3,17- Dione

≤ 0.5 %

18-methyl-estr-4-ene-3-one-17(3 -ol

≤ 0.5%

18-methyl-estr-4-ene-3,17-dione

≤ 0.5 %

Sin­gle Impurity

≤0.5%

Total Impu­ri­ties

≤ 3.0%

Shelf Life

2 years

Stor­age

Under room tem­per­a­ture away from light

Known Appli­ca­tion

11A-HYDROXY-18-METHYL-ESTR-4-ENE-3,17-DIONE pos­sess­es antian­dro­genic activ­i­ty. It can bind to andro­gen recep­tors, inhibit­ing the action of andro­gens. This poten­tial makes Mifepri­s­tone use­ful in the treat­ment of cer­tain andro­­gen-depen­­dent tumors (such as breast can­cer and prostate can­cer) and con­di­tions char­ac­ter­ized by exces­sive andro­gen levels.

And 11A-HYDROXY-18-METHYL-ESTR-4-ENE-3,17-DIONE can bind to glu­co­cor­ti­coid recep­tors and dis­play some glu­co­cor­ti­coid recep­tor antag­o­nis­tic activ­i­ty. This poten­tial indi­cates its pos­si­ble appli­ca­tion in the treat­ment of cer­tain con­di­tions involv­ing glu­co­cor­ti­coid excess and mod­u­la­tion of the bio­log­i­cal effects of glucocorticoids.

11A-HYDROXY-18-METHYL-ESTR-4-ENE-3,17-DIONE has also shown oth­er bio­log­i­cal activ­i­ties such as anti-insulin effects, anti­co­ag­u­lant effects, and anti­tu­mor effects. These actions are being inves­ti­gat­ed and explored to fur­ther under­stand the poten­tial clin­i­cal appli­ca­tions of Mifepristone.

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Lim­it­ed (http://​www​.cam​ing​.com/).

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