Structure of ABT 199 CAS 1257044 40 8 - ABT-199 CAS 1257044-40-8 Iden­ti­fi­ca­tion Prop­er­ties Safe­ty Data Spec­i­fi­ca­tions andamp ; Oth­er Information Links

Iden­ti­fi­ca­tion

CAS Number

1257044-40-8

Name

ABT-199

Syn­onyms

4-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide [ACD/IUPAC Name] 4-(4-{[2-(4-Chlorophényl)-4,4-diméthyl-1-cyclohexén-1-yl]méthyl}-1-pipérazinyl)-N-({3-nitro-4-[(tétrahydro-2H-pyran-4-ylméthyl)amino]phényl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide [French] [ACD/IUPAC Name] 4-(4-{[2-(4-Chlorphenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamid [Ger­man] [ACD/IUPAC Name] ABT 199 ABT199 ABT-199 Ben­za­mide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)- [ACD/​Index Name] GDC 0199 vene­to­clax [Span­ish] [INN] Vene­to­clax [INN] [USAN] véné­to­clax [French] [INN] vene­to­clax­um [Latin] [INN] венетоклакс [Russ­ian] [INN] فينيتوكلاكس [Ara­bic] [INN] 维奈克拉 [Chi­nese] [INN] [1257044-40-8] 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)phenylsulfonyl)benzamide 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide 4-{4-[(4′-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1′-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro-4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide ABT-199 (GDC-0199) ABT199, ABT 199, GDC0199, GDC-0199 ABT-199|GDC-0199 GDC0199 GDC-0199 GDC-0199 ;ABT199 ;ABT 199 ;GDC0199 ;GDC 0199;Venetoclax MFCD23160052 N54AIC43PW UNII :N54AIC43PW UNII-N54AIC43PW Ven­clex­ta Ven­clex­ta TM Vene­to­clax (ABT-199, GDC-0199)

Mol­e­c­u­lar Structure

Structure of ABT 199 CAS 1257044 40 8 - ABT-199 CAS 1257044-40-8

Struc­ture of ABT-199 CAS 1257044-40-8

SMILES

CC1(CCC(=C(C1)c2ccc(cc2)Cl)CN3CCN(CC3)c4ccc(c(c4)Oc5cc6cc[nH]c6nc5)C(=O)NS(=O)(=O)c7ccc(c(c7)[N+](=O)[O-])NCC8CCOCC8)C

Std­InChI

InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

Std­InChIKey

LQB­VN­QS­MG­BZMKD-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C45H50ClN7O7S

Mol­e­c­u­lar Weight

868.44

Prop­er­ties

Appear­ance

Yel­low pow­der

Safe­ty Data

Sig­nal Word

Warn­ing

WGK Germany

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our ABT-199 CAS 1257044-40-8

Stan­dard

Enter­prise stan­dard

Iden­ti­fi­ca­tion Methods

HNMR,HPLC

Puri­ty

99%min

Pack­age

Accord­ing to cus­tomer require­ments to pack­ag­ing

Stor­age

Under the room tem­per­a­ture and away from light

Appli­ca­tion

ABT-199 is a new type of anti-can­cer drug.ABT-199 (GDC-0199) is a Bcl-2-selec­­tive inhibitor with Ki of 4800-fold more selec­tive ver­sus Bcl-xL and Bcl-w, and no activ­i­ty to Mcl-1.

Gen­er­al View of Documents

ABT 199 CAS 1257044 40 8 HNMR - ABT-199 CAS 1257044-40-8

ABT-199 CAS 1257044-40-8 HNMR

ABT 199 CAS 1257044 40 8 HPLC - ABT-199 CAS 1257044-40-8

ABT-199 CAS 1257044-40-8 HPLC

Links

This prod­uct is devel­oped by our RD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​a​b​t​-​1​9​9​-​c​a​s​-​1​2​5​7​0​4​4​-​4​0​-8/

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