Iden­ti­fi­ca­tion

CAS Number

64485-93-4

Name

Cefo­taxime sodi­um

Syn­onyms

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-, sodi­um salt, (6R,7R)- (1:1) Sodi­um (6R,7R)-3-(acetoxymethyl)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate sodi­um (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (+)-Cefo­taxime Sodi­um (+)-Cefo­taxime sodi­um salt (6R,7R)-3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodi­um salt (6R,7R)-3-acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate Cef­cil Cefo­tax­im sodi­um Cefo­tax­im sodi­um salt Cefo­taxime Cefo­taxime sodi­um Cefo­taxime Sodi­um Salt Cefo­taxime­sodi­um CLAFORAN Claforan CTX Pre­tor RU-24756 Sodi­um sodi­um 3-(acetoxymethyl)-7β-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2,3-didehydrocepham-2-carboxylate sodi­um 3-(acetoxymethyl)-7β-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3,4-didehydrocepham-4-carboxylate Sodi­um 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate Sodi­um cefo­taxime Sodi­um ; (6R,7R)-3-acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Mol­e­c­u­lar Structure

Structure of Cefotaxime sodium Sterile CAS 64485-93-4

SMILES

[Na+].O=C2N1/C(=C(CS[C@@H]1[C@@H]2NC(=O)C(=NOC)/c3nc(sc3)N)COC(=O)C)C([O-])=O

Std­InChI

InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

Syd­InChIKey

AZZMGZXN­T­DTSME-JUZD­KLSS­SA-M

Mol­e­c­u­lar Formula

C16H16N5NaO7S2

Mol­e­c­u­lar Weight

477.44

EINECS Number

264-915-9

MDL Number

MFCD00079073

Beil­stein Reg­istry Number

5711411

Prop­er­ties

Appear­ance

White to pale yel­low crys­talline pow­der

Sol­u­bil­i­ty

H2O : sol­u­ble (aque­ous solu­tions of pH 4.3-6.2 are sta­ble up to 3 weeks at 2-8 °C.)

Suit­abil­i­ty

Plant cell cul­ture test­ed

Safe­ty Data

Sym­bol

health-hazard-jpgGHS08

Sig­nal word

Dan­ger

Haz­ard Statements

H317-H334

Pre­cau­tion­ary Statements

P261-P280-P342+P311

Haz­ard Codes (Europe)

Xn

Risk State­ments (Europe)

42/43

Safe­ty State­ments (Europe)

22-36/37

WGK Germany

2 

RTECS

XI0250000

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Cefo­taxime sodi­um Ster­ile CAS 64485-93-4

Stan­dard

USP32

Iden­ti­fi­ca­tion

IR Spec­trum, HPLC RT, Sodi­um

Clar­i­ty

Clear

Col­or of Solution

0.2 max(430nm,10% Solu­tion)

Spe­cif­ic Rotation

+56°～+64°

PH

4.5～6.5

Loss on Drying

3.0% max

Indi­vid­ual Impurity

1.0% max

Total impu­ri­ties

3.0% max

Steril­i­ty

Ster­ile

Bac­te­r­i­al Endotoxins

0.20 USP EU/​mg max

Par­tic­u­late Matter

10um NMT 6000 min 25 um NMT 600 min

Assay(HPLC)

916～964 ug/​mg (as Cefo­taxime, anhy­drous)

Stor­age

Pre­serve in tight con­tain­er, 2-8 °C at dry place, away from light.

Pack­age

5kg/tin,10kg/tin

Known Appli­ca­tion

Broad spec­trum third gen­er­a­tion cephalosporin antibi­ot­ic.

Biochem/​physiol Actions

Cefo­tax­im inhibits bac­te­r­i­al cell wall syn­the­sis by bind­ing to peni­­cillin-bind­ing pro­teins (PBPs) which inhibits the final transpep­ti­da­tion step of pep­ti­do­gly­can syn­the­sis in bac­te­r­i­al cell walls. As a result, bac­te­ria lyse due to cell wall autolyt­ic enzymes. Cefo­taxime, a cephalosporin antibi­ot­ic, is active against both gram-neg­a­­tive and gram-pos­i­­tive bac­te­ria. In addi­tion, cefo­taxime blocks the divi­sion of cyanobac­te­ria and low­er plant organelles/​plastids such as the pho­to­syn­thet­ic organelles of Glau­co­phytes and chloro­plas­ts of bryophytes.

Wat­­son-Int Link

http://​wat​son​-int​.com/​C​e​f​o​t​a​x​i​m​e​-​S​o​d​i​u​m​-​S​t​e​r​i​l​e​_​C​A​S​_​6​4​4​8​5​-​9​3​-​4​.​h​tml