Gem­fi­brozil CAS 25812-30-0

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• Prop­er­ties
• Safe­ty Data
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Iden­ti­fi­ca­tion

CAS Number

25812-30-0

Name

Gem­fi­brozil

Syn­onyms

2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
247-280-2 [EINECS]
25812-30-0 [RN]
5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid [ACD/IUPAC Name]
5-(2,5-Dimethylphenoxy)-2,2-dimethylpentansäure [Ger­man] [ACD/IUPAC Name]
Acide 5-(2,5-diméthylphénoxy)-2,2-diméthylpentanoïque [French] [ACD/IUPAC Name]
Gem­fi­brozil [BAN] [INN] [USAN] [Wiki]
Gem­fi­brozi­lo [Span­ish] [INN]
gem­fi­brozilum [Latin]
gevilon
MFCD00079335 [MDL num­ber]
Pen­tanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- [ACD/​Index Name]
Gen-Fibro
Gen­lip
114772-53-1 [RN]
1184986-45-5 [RN]
1881200 [Beil­stein]
2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid
2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
2,2-Dimethyl-5-(2,5-zlyloxy)valeric acid
4TX
5-(2,5-Dimethylphenoxy)-2,2-DimethylpentamoicAcid
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
5-(2,5-Dimethyl-Phenoxy)-2,2-Dimethyl-Pentanoic Acid
5-(2,5-dimethylphenoxy)-2,2-dimethyl-valeric acid
5-[(2,5-dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
Aus­gem
Bolu­tol
Brozil
C07020
Chole­spid
CI-7
Clearol
DB01241
Decre­li
Decre­lip
Elmo­gan
Emfib
Fetinor
Fibra­tol
Fibroc­it
GEM
Gem­cor
Gem­fi 1A Phar­ma
Gem­fib­ril
Gem­fi­bro­max
Gem­fi­brosil
GEM­­FI­BROZIL-D6
Gem­fi­brozi­lo
Gem­fi­brozi­lo [INN-Span­ish]
gem­fi­brozilum
Gem­fi­brozilum [INN-Latin]
Gemhexal
Gem­lipid
Gem­n­pid
Gem-S
Gen-Fibro®
Gevilon Uno
GFZ
Gozid
Hidil
Hipolix­an
Inno­gen [Wiki]
Ipolipid
Jezil
Jezil®
KS-5192
Lanaterom
Lifi­bron
Lipazil
Lip­igem
Lipi­ra
Lip­izyl
Lipox Gem­fi
Lipozid
LIPUR
Litarek
Lopid [Wiki]
Lopid R
Lopid ;CI-719
Low-Li
Low-Lip
Micol­ip
Nor­molip
Organo­lipid
pEINECS 247-280-2
Pilder
pMi­coli
pNor­moli
Polyx­it
pPen­tanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
pRenabrazin
Prog­emzal
pSyn­brozil
Redu­cel
Reg­uli
Reg­ulip
Renabrazin
Sineli
Sinelip
Syn­brozil
Tabor­cil
Ten­troc
TEVA-A
Trialmin
Valer­ic acid, 2,2-dimethyl-5-(2,5-xylyloxy)-
гемфиброзил [Russ­ian]
جامفيبروزيل [Ara­bic]
吉非罗齐 [Chi­nese]

SMILES

Cc1ccc(c(c1)OCC­CC(C)(C)C(=O)O)C

Std­InChI

InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

Std­InChIKey

HEMJJK­B­WT­P­KO­JG-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C₁₅H₂₂O₃

Mol­e­c­u­lar Weight

250.333

EINECS

247-280-2

MDL Number

MFCD00079335

Prop­er­ties

Appear­ance

White crys­talline powder

Safe­ty Data

Sym­bol

GHS07

Sig­nal Word

Warn­ing

Haz­ard statements

Pre­cau­tion­ary Statements

WGK Germany

3

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Assay

98% min

Heavy Met­als

≤20ppm

Water

≤0.25%

Any oth­er impurity

≤0.08%

Total impu­ri­ty

≤0.5%

Eth­yl formate

≤5000ppm

Shelf Life

3 years

Stor­age

Under room tem­per­a­ture away from light

Known Appli­ca­tion

Gem­fi­brozil (1), with the chem­i­cal name 2,2-dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid, is a fibrate class lipid-reg­u­lat­ing med­ica­tion derived from clofi­brate. It was intro­duced to the mar­ket in the Unit­ed States in 1982. Gem­fi­brozil over­comes the seri­ous hepat­ic tox­i­c­i­ty asso­ci­at­ed with ear­li­er lipid-low­er­ing drugs such as clofi­brate while retain­ing its effi­ca­cy. It pro­motes the break­down of periph­er­al fat, reduces the hepat­ic uptake of free fat­ty acids, there­by decreas­ing intra­hep­at­ic triglyc­eride for­ma­tion. Addi­tion­al­ly, it inhibits the syn­the­sis of very-low-den­si­­ty lipopro­tein (VLDL) and reduces the gen­er­a­tion of VLDL.

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Lim­it­ed (http://​www​.cam​ing​.com/).

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