Iden­ti­fi­ca­tion

CAS Number

132866-11-6

Name

Ler­cani­dip­ine HCL

Syn­onyms

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochlo­ride Zani­dip Lerdip

Mol­e­c­u­lar Structure

Structure of Lercanidipine HCL CAS 132866-11-6

SMILES

Cl.[O-][N+](=O)c1cccc(c1)C4C(=C(/NC(=C4C(=O)OC(C)(C)CN(CCC(c2ccccc2)c3ccccc3)C)C)C)C(=O)OC

Std­InChI

InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3 ;1H

Std­InChIKey

WMFY­OYKPJL­R­MJI-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C36H41N3O6.HCL

Mol­e­c­u­lar Weight

648.19

Prop­er­ties

Appear­ance

Light yel­low to yel­low pow­der

Melt­ing Point

185-190°C

Boil­ing Point

712.5 °C at 760 mmHg

Flash Point

384.7 °C

Safe­ty Data

Sym­bol

skull-jpgGHS06

Sig­nal Word

Dan­ger

Haz­ard Statements

H301

Pre­cau­tion­ary Statements

P301 + P310 

Per­son­al Pro­tec­tive Equipment

Eye­shields, Faceshields, Gloves, type P2 (EN 143) res­pi­ra­tor car­tridges

Haz­ard Codes (Europe)

T

Risk State­ments (Europe)

25

Safe­ty State­ments (Europe)

36/37-45

RIDADR

UN 2811 6.1/PG 3 

WGK Germany

3 

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Ler­cani­dip­ine HCL CAS 132866-11-6

Puri­ty

99.5% min

Sin­gle Impurity

0.07% max

Loss on Drying

0.5% max

Heavy Met­als

20 ppm max

Known Actions

It is a L-type vas­cu­lar chan­nel antag­o­nist ; L-type car­diac chan­nel ago­nist volt­age-depen­­dent and high­ly lipophylic com­pound, which exhibits a slow­er onset and longer dura­tion of action than oth­er cal­ci­um chan­nel antag­o­nists ; an anti­hy­per­ten­sive agent in patients with mild-to-mod­­er­ate hyper­ten­sion ; more vasos­e­lec­tive than lacidip­ine and amlodip­ine.

Known Appli­ca­tion

It is also called Ler­cani­dip­ine or Zani­dip, which works by relax­ing and open­ing the blood ves­sels allow­ing the blood to cir­cu­late more freely around the body. This low­ers the blood pres­sure and allows the heart to work more effi­cient­ly.

Pro­duc­tiv­i­ty

500kg/​month

Stor­age

2-8°C away from light, keep dry.

Wat­­son-Int Link

ttp://watson-int.com/Lercanidipine-HCL_CAS_132866-11-6.html