sds page 204 28 3 - Recombinant Human Mucosae-associated Epithelial Chemokine/CCL28 (rHuMEC/CCL28) CAS 204-28-1816

Offi­cial Full Name

Recom­bi­nant Human Mucosae-asso­­ci­at­ed Epithe­lial Chemokine/​CCL28 (rHuMEC/​CCL28)

CAS Num­ber (Or Wat­son Num­ber for Non-CAS Products)

204-28-1816

Syn­onyms

CCK1

Squence

region 204 28 1 - Recombinant Human Mucosae-associated Epithelial Chemokine/CCL28 (rHuMEC/CCL28) CAS 204-28-1816

Amino Acid Sequence

SEAILPI­ASS CCTEVSH­HIS RRLLERVN­MC RIQRADGD­CD LAAV­IL­HVKR RRICVSPHNH TVKQWMKVQA AKKNGKGN­VC HRKKHHGKRN SNRAHQGKHE TYGHK­T­PY

Syn­onyms

CCK1

Acces­sion

Q9NRJ3

Gene ID

56477

Sum­ma­ry

CCL28 belongs to CC fam­i­ly chemokine, also named mucosae-asso­­ci­at­ed epithe­lial chemokine (MEC). The CCL28 cDNA is locat­ed on Chr.5 in humans, and the mRNA of CCL28 is high­ly expressed by epithe­lial cells of diverse tis­sues includ­ing nor­mal and patho­log­i­cal colon, sali­vary gland, mam­ma­ry gland, tra­chea and rec­tum. The amino acids sequence of human and mouse CCL28 shares 83 % iden­ti­ty, when the pro­tein is processed to be the mature form. CCL28 is sig­nal­ing through CCR3 and CCR10, and chemo­tac­tic for rest­ing CD4, CD8 T-cells and eosinophils.

Source

Escherichia coli.

Mol­e­c­u­lar Weight

Approx­i­mate­ly 12.4 kDa, a sin­gle non-gly­­co­sy­lat­ed polypep­tide chain con­tain­ing 108 amino acids.

Bio­log­i­cal Activity

Ful­ly bio­log­i­cal­ly active when com­pared to stan­dard. The bio­log­i­cal activ­i­ty deter­mined by a chemo­taxis bioas­say using human lym­pho­cytes is in a con­cen­tra­tion range of 1.0-10.0 ng/​ml.

Appear­ance

Ster­ile fil­tered white lyophilized (freeze-dried) pow­der.

For­mu­la­tion

Lyophilized from a 0.2 um fil­tered con­cen­trat­ed solu­tion in 20 mM PB, pH 7.4, 130 mM NaCl.

Endo­tox­in

Less than 1 EU/​ug of rHuMEC/​CCL28 as deter­mined by LAL method.

Recon­sti­tu­tion

We rec­om­mend that this vial be briefly cen­trifuged pri­or to open­ing to bring the con­tents to the bot­tom. Recon­sti­tute in ster­ile dis­tilled water or aque­ous buffer con­tain­ing 0.1 % BSA to a con­cen­tra­tion of 0.1-1.0 mg/​mL. Stock solu­tions should be appor­tioned into work­ing aliquots and stored at ≤ -20 °C. Fur­ther dilu­tions should be made in appro­pri­ate buffered solu­tions.

Sta­bil­i­ty and Storage

Use a man­u­al defrost freez­er and avoid repeat­ed freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as sup­plied.- 1 month, 2 to 8 °C under ster­ile con­di­tions after recon­sti­tu­tion.- 3 months, -20 to -70 °C under ster­ile con­di­tions after recon­sti­tu­tion.

Ref­er­ences

Puri­ty

> 97 % by SDS-PAGE and HPLC analy­ses.

SDS-PAGE

sds page 204 28 2 - Recombinant Human Mucosae-associated Epithelial Chemokine/CCL28 (rHuMEC/CCL28) CAS 204-28-1816

Pack Size

5ug/​100ug/​500ug

Safe­ty Data Sheet (SDS) Down­load

Click to download

Tech­ni­cal Data Sheet (TDS) Down­load

Click to download

Links

This prod­uct is brand­ed by ChemWhat and sold through our web­site and here is the cor­re­spond­ing link Recom­bi­nant Human Mucosae-asso­­ci­at­ed Epithe­lial Chemokine/​CCL28 (rHuMEC/​CCL28) on ChemWhat

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