Official Full Name
Recombinant Murine Interleukin-10 (rMuIL-10)
CAS Number (Or Watson Number for Non-CAS Products)
Amino Acid Sequence SRGQYSREDN NCTHFPVGQS HMLLELRTAF SQVKTFFQTK DQLDNILLTD SLMQDFKGYL GCQALSEMIQ FYLVEVMPQA EKHGPEIKEH LNSLGEKLKT LRMRLRRCHR FLPCENKSKA VEQVKSDFNK LQDQGVYKAM NEFDIFINCI EAYMMIKMKS
) is encoded by the IL10
gene and expressed in monocytes and Type 2 T helper cells (Th2). The biological activities of IL-10
are mediated by the IL-10
receptor complex, which is composed of the ligand-binding IL-10
Ralpha/R1 and the accessory IL-10
Rβ/R2 subunits. IL-10
is capable of inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2
produced by activated macrophages and by T helper cells. IL-10
is classified as a class 2 cytokine which consist of IL-10
, several interferons and interferon-like molecules. Mature murine IL-10
shares 70 %-77 % amino acid sequence identity with human, bovine, porcine IL-10
, but murine IL-10
does not act on human cells.
Approximately 18.7 kDa, a single non-glycosylated polypeptide chain containing 160 amino acids.
Fully biologically active when compared to standard. The ED50
as determined by a cell proliferation assay using murine MC
/9-2 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU
Sterile filtered white lyophilized (freeze-dried) powder.
Lyophilized from a 0.2 um filtered solution in PBS
, pH 7.4.
Less than 1 EU
/ug of rMuIL-10 as determined by LAL
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 10 mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
> 97 % by SDS-PAGE
Safety Data Sheet (SDS) Download
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Technical Data Sheet (TDS) Download
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