Selume­tinib CAS 606143-52-6

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• Prop­er­ties
• Safe­ty Data
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Iden­ti­fi­ca­tion

CAS Number

606143-52-6

Name

Selume­tinib CAS 606143-52-6

Syn­onyms

1H-Ben­z­im­i­­da­­zole-6-car­box­am­ide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl- [ACD/​Index Name]
5-[(4-Brom-2-chlorphenyl)amino]-4-fluor-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazol-6-carboxamid [Ger­man] [ACD/IUPAC Name]
5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide [ACD/IUPAC Name]
5-[(4-Bromo-2-chlorophényl)amino]-4-fluoro-N-(2-hydroxyéthoxy)-1-méthyl-1H-benzimidazole-6-carboxamide [French] [ACD/IUPAC Name]
606143-52-6 [RN]
6UH91I579U
selume­tinib [INN] [USAN] [Wiki]
selume­tinib [Span­ish] [INN]
sélumé­tinib [French] [INN]
selume­tinibum [Latin] [INN]
1777807-55-2 [RN]
1H-Ben­z­im­i­­da­­zole-6-car­box­am­ide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl
3EW
5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
5-(4-Bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-5-benzimidazolecarboxamide
6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide
6-(4-Bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide
6-[(4-bromo-2-chlorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-5-benzimidazolecarboxamide
6-[(4-bromo-2-chlorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
6-[(4-bromo-2-chloro-phenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-benzimidazole-5-carboxamide
Array142886
AZD6244, ARRY-142886, ARRY-886
CHEMBL1614701
D09666
MAP2K1
MFCD11977472 [MDL num­ber]
sélumé­tinib
Selume­tinib (USAN/INN)
selume­tinibum
UNII :6UH91I579U
UNII-6UH91I579U
селуметиниб [Russ­ian]

SMILES

Cn1cnc2c1cc(c(c2F)Nc3ccc(cc3Cl)Br)C(=O)NOC­CO

Std­InChI

InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

Std­InChIKey

CYOHGAL­H­­FOKKQC-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C₁₇H₁₅BrClFN₄O₃

Mol­e­c­u­lar Weight

457.681

EINECS

207-313-3

MDL Number

MFCD11977472

Prop­er­ties

Appear­ance

White or off-white powder.

Safe­ty Data

Sym­bol

GHS07, GHS08

Sig­nal Word

Warn­ing

Haz­ard statements

Pre­cau­tion­ary Statements

WGK Germany

3

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

Puri­ty

99% min

Water

0.5%max

RESIDUE ON IGNI­TION

0.2 %max

Eth­yl acetate

≤5000ppm

Methanol

≤5000ppm

Dichloromethane

≤600ppm

THF

≤500ppm

Petro­le­um ether

≤5000ppm

Shelf Life

2 years

Stor­age

Under room tem­per­a­ture away from light

Known Appli­ca­tion

Selume­tinib CAS 606143-52-6 is used for the treat­ment of advanced non-small cell lung can­cer (NSCLC). Selume­tinib pri­mar­i­ly inhibits the growth of var­i­ous tumors, includ­ing melanomas with B-Raf muta­tions and non-small cell lung can­cer (NSCLC) with K-Ras muta­tions, by reg­u­lat­ing the key pro­tein kinase MEK in the Ras-Raf-MEK-ERK path­way. It is main­ly employed in the treat­ment of dis­eases such as cholan­gio­car­ci­no­ma, col­orec­tal can­cer, and NSCLC. Cur­rent­ly, Selume­tinib is in phase III clin­i­cal tri­als for the treat­ment of non-small cell lung cancer.

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Lim­it­ed (http://​www​.cam​ing​.com/).

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