Sotora­sib CAS 2296729-00-3

• Iden­ti­fi­ca­tion
• Prop­er­ties
• Safe­ty Data
• Spec­i­fi­ca­tions & Oth­er Information
• Links
• Quick Inquiry

Iden­ti­fi­ca­tion

CAS Number

2296729-00-3

Name

Sotora­sib

Syn­onyms

2252403-56-6 [RN]
4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluor-7-(2-fluor-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-on [Ger­man] [ACD/IUPAC Name]
4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one [ACD/IUPAC Name]
4-[(2S)-4-Acryloyl-2-méthyl-1-pipérazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphényl)-1-(2-isopropyl-4-méthyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one [French] [ACD/IUPAC Name]
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one
Lumakras [Trade name]
Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- [ACD/​Index Name]
sotora­sib [USAN]
(1R)-4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
2296729-00-3 [RN]
2296729-00-3 (race­mate)
2296729-66-1 [RN]
4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one
AMG 510
AMG510
AMG-510
AMG-510 race­mate
BS-16684
KRAS
MFCD32062763
sotora­sib ; sotorasibum

SMILES

CC1=CC=NC(C(C)C)=C1N1C2N=C(C3C(O)=CC=CC=3F)C(F)=CC=2C(=NC1=O)N1CCN(C[C@@H]1C)C(=O)C=C

Std­InChI

InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

Std­InChIKey

NXQK­SXLF­SAE­QCZ-SFHVUR­JK­SA-N

Mol­e­c­u­lar Formula

C₃₀H₃₀F₂N₆O₃

Mol­e­c­u­lar Weight

560.594

MDL Number

MFCD32880274

Prop­er­ties

Appear­ance

Safe­ty Data

Sym­bol

Sig­nal Word

Warn­ing

WGK Germany

3

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

Puri­ty

Pro­duc­tiv­i­ty

Known Appli­ca­tion

Sotora­sib CAS 2296729-00-3 is a selec­tive cova­lent inhibitor of KRAS G12C for the treat­ment of patients with advanced KRAS G12C mutat­ed non-small cell lung can­cer (NSCLC) who have received pri­or sys­temic therapy.

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our R&D com­pa­ny Wat­son­noke Sci­en­tif­ic Lim­it­ed (http://​www​.wat​son​noke​.com/).

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly.