Iden­ti­fi­ca­tion

CAS Number

288383-71-1

Name

4-chloro-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazoline

Syn­onyms

Tan­du­tinib inter­me­di­ate MLN518 CT53518

Mol­e­c­u­lar Structure

Structure of this intermediate CAS 288383-71-1

SMILES

Clc3ncnc2cc(OCCCN1CCCCC1)c(OC)cc23

Std­InChI

InChI=1S/C17H22ClN3O2/c1-22-15-10-13-14(19-12-20-17(13)18)11-16(15)23-9-5-8-21-6-3-2-4-7-21/h10-12H,2-9H2,1H3

Std­InChIKey

QMP­MEXB­H­MIYN­GL-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C17H22ClN3O2

Mol­e­c­u­lar Weight

335.83

Prop­er­ties

Appear­ance

White or almost white crys­talline pow­der

Refrac­tive Index

n20/D1.583(lit.)

Boil­ing Point

485.69 °C at 760 mmHg

Flash Point

247.537 °C

Den­si­ty

1.215 g/​ml

Safe­ty Data

Sym­bol

exclamation-mark-jpgGHS07

Sig­nal Word

Warn­ing

Haz­ard Statements

H315-H319-H335

Pre­cau­tion­ary Statements

P261-P305 + P351 + P338

Per­son­al Pro­tec­tive Equipment

dust mask type(N95) US, Eye Shields, Gloves

Haz­ard Codes (Europe)

Xi

Risk State­ments (Europe)

36/37/38-52/53

Safe­ty State­ments (Europe)

26-36

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Tan­du­tinib inter­me­di­ate CAS 288383-71-1

Puri­ty

98%min(By HPLC)

Iden­ti­fi­ca­tion

HNMR, HPLC

Known Appli­ca­tion

It is an inter­me­di­ate(CAS 288383-71-1) of the Tan­du­tinib, which is an oral­ly active mul­ti­tar­get­ed tyro­sine kinase inhibitor that is cur­rent­ly under eval­u­a­tion for the treat­ment of glioblas­toma and has been used in the treat­ment of leukemia.

Pro­duc­tiv­i­ty

kg scale

Wat­­son-Int Link

http://​wat​son​-int​.com/​I​n​t​e​r​m​e​d​i​a​t​e​-​o​f​-​t​a​n​d​u​t​i​n​i​b​_​C​A​S​_​2​8​8​3​8​3​-​7​1​-​1​.​h​tml