Identification
Properties
Safety Data
Specifications and Other Information
Links
Identification
CAS Number
102691-36-1
Name
2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite
Synonyms
102691-36-1 [RN]
2-Cyanethyl-N,N,N’,N’-tetraisopropylphosphorodiamidoit [German] [ACD/IUPAC Name]
2-Cyanoethyl N,N,N’,N’-tetraisopropyldiamidophosphite
2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidoite [ACD/IUPAC Name]
2-cyanoethyl N,N,N’,N’-tetrapropan-2-ylphosphorodiamidoite
2-Cyanoethyl-N,N,N’,N’-tetraisopropylphosphorodiamidite
2-Cyanoethyltetraisopropylphosphorodiamidite
N,N,N’,N’-Tétraisopropylphosphorodiamidoite de 2-cyanoéthyle [French] [ACD/IUPAC Name]
Phosphorodiamidous acid, N,N,N’,N’-tetrakis(1-methylethyl)-, 2-cyanoethyl ester [ACD/Index Name]
Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester
[102691-36-1]
¦Â-Cyanoethyl-N,N,N`,N`-tertraisopropylphosphorodiamidite
2-cyanoethyl N,N,Nand#39,N’-tetraisopropyl-phosphordiamidite
2-Cyanoethyl N,N,N’,N’-tetra(prop-2-yl)phosphorodiamidoite
2-cyanoethyl N,N,N’,N’-tetraisopropyl-phosphordiamidite
2-Cyanoethyl N,N,N’,N’-Tetraisopropylphosphordiamidite
2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite
2-Cyanoethyl N,N,N’,N’-tetrakis(isopropyl)phosphorodiamidite
2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite
2-Cyanoethyl tetraisopropylphosphorodiamidite
2-CyanoethylN,N,N’,N’-tetraisopropylphosphorodiamidite
3-((bis(diisopropylamino)phosphanyl)oxy)propanenitrile
3-((Bis(diisopropylamino)phosphino)oxy)propanenitrile
3-((Bis(diisopropylamino)phosphino)oxy)-propanenitrile
3-((Bis(diisopropylamino)phosphino)-oxy)propanenitrile
3-({bis[bis(propan-2-yl)amino]phosphanyl}oxy)propanenitrile
3-(bis(diisopropylamino)phosphinooxy)propanenitrile
3-{bis[bis(methylethyl)amino]phosphinooxy}propanenitrile
3-Bis(diisopropylamino)phosphanyloxypropanenitrile
3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
3-bis[di(propan-2-yl)amino]phosphinooxypropanenitrile
600-337-9 [EINECS]
Bis(diisopropylamino)(2-cyanoethoxy)phosphine
bis(N,N-diisopropylamino)-2-cyanoethoxyphosphine
Cetipd
MFCD00012213 [MDL number]
P-Reagent
SS-7739
SMILES
CC(C)N(C(C)C)P(N(C(C)C)C(C)C)OCCC#N
StdInChI
InChI=1S/C15H32N3OP/c1-12(2)17(13(3)4)20(19-11-9-10-16)18(14(5)6)15(7)8/h12-15H,9,11H2,1-8H3
StdInChIKey
RKVHNYJPIXOHRW-UHFFFAOYSA-N
Molecular Formula
C15H32N3OP
Molecular Weight
301.41
Beilstein Registry Number
3590103
MDL Number
MFCD00012213
Properties
Appearance
Colorless and Clear liquid
Refractive Index
n20/D 1.470(lit.)
Boiling Point
100 °C/0.5 mmHg(lit.)
Density
0.949 g/mL at 25 °C(lit.)
Flash Point
60°C
Safety Data
Symbol
GHS02, GHS08Signal Word
Danger
Hazard Statements
Precautionary Statements
P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
RIDADR
UN 1993C 3 / PGIII
WGK Germany
3
Specifications and Other Information of Our 2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphorodiamidite CAS 102691-36-1
Standard
Enterprise standard
Identification Methods
H-NMR,P-NMR
Purity
99.5%min
Manufacturing Capacity
500kg-800kg/month
Storage
Store at low temperature (2-8°C) under nitrogen, sealed, dry, and protected from light.
Application
1. DNA/RNA Synthesis : Used to prepare nucleoside phosphoramidite monomers, serving as a crucial upstream reagent in solid-phase oligonucleotide synthesis.
2. Modified Oligonucleotides : Used in the synthesis of LNA, modified nucleosides, functionalized DNA/RNA, and antisense oligonucleotides.
3. Nucleic Acid Drugs : Serving the research and development and production of nucleic acid drugs such as siRNA and ASO.
4. Molecular Biology : Used in the synthesis of DNA primers, probes, and other custom oligonucleotides.
5. Phospholipid Synthesis : Can be used for the phosphorylation construction of some phospholipids/glycerophospholipids.
6. Carbohydrates and Glycopeptides : Can be used in the synthesis of phosphorus-containing sugars, glycopeptides, and other phosphorylated biomolecules.
7. Medicinal Chemistry : Used in the synthesis of phosphorus-containing nucleosides, nucleoside analogs, and other phosphorus-containing bioactive molecules.
Key Advantages
- Mature Application in Nucleic Acid Synthesis :
It is an important reagent in classic 2-cyanoethyl phosphoramidite chemistry, widely used in the synthesis of DNA/RNA oligonucleotides. - High Reactivity :
The P(III) center exhibits high reactivity, reacting efficiently with alcohol hydroxyl groups under the action of activators such as tetrazole and DCI to form phosphoramidite intermediates. - Suitable for Automated Solid-Phase Synthesis :
The formed nucleoside phosphoramidites can be used in automated oligonucleotide synthesizers, suitable for continuous, repetitive solid-phase synthesis processes. - Easy Removal of 2-Cyanoethyl Protecting Group :
β-Cyanoethyl is a classic phosphate protecting group, which can be easily removed during post-processing, facilitating the final acquisition of a stable phosphate/phosphodiester backbone. - Wide Applicability :
Not only suitable for ordinary DNA/RNA, but also for the synthesis of modified nucleosides, LNA, functionalized oligonucleotides, and other phosphorylated biomolecules. - High value to the nucleic acid drug industry chain. Its downstream applications cover oligo synthesis, ASO, siRNA, gene detection, molecular diagnostics and nucleic acid drug research and development/production, thus having a relatively clear industrial application market.
General View of Documents
Links
This product is developed by our RandD company Caming Pharmaceutical Ltd(http://www.caming.com/)
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