Car­bo­hy­drate and Nucleotide Development

ULCHO Bio­chem­i­cal Ltd can pro­fes­sion­al­ly offer cus­tom syn­the­sis of car­bo­hy­drates, such as car­bo­hy­drate-based inter­me­di­ates, car­bo­hy­drate-based drugs and gly­cosi­dase sub­strates, with good qual­i­ty, com­pet­i­tive prices and fast delivery.

ULCHO can sup­ply car­bo­hy­drate-based build­ing blocks includ­ing gly­co­syl halides, thio­gly­co­sides, amino sug­ars, gly­cals, deoxy deriv­a­tives, uron­ic acid deriv­a­tives, alditols, acetal deriv­a­tives, alkyl gly­co­side deter­gents, oligosac­cha­rides, car­bo­hy­drate-based drugs, and so on. Our some fea­tured prod­ucts are as follows.

• Thio­gly­co­sides : Iso­propyl-β-D-thio­galac­topy­ra­noside, Eth­yl-β-D- thiogalactopyranoside
• Gly­cals : 3,4,6-Tri-O-acetyl-D-galactal, 3,4,6-Tri-O-benzyl-D-glucal
• Acetates : β-D-Galac­tosamine pen­taac­etate, β-D-Glu­cosamine Pen­taac­etate, α-D-Man­nose pentaacetate
• Uron­ic acid deriv­a­tives : L-galactono-1,4-lactone, L-Gulono-1,4-lactone
• Acetal deriv­a­tives : 2,3:5,6-Di-O-isopropylidene-α-D-mannofuranose, 1,2:3,4-Di-O-isopropylidene-α-D-galactopyranose, 1,2-O-Isopropylidene-α-D-xylose, 1,2:5,6-Di-O- iso­propy­li­dene-α-D-allo­fu­ra­nose, Methyl 4,6-O-benzylidene-α-D-glucopyranoside
• Ben­zy­lat­ed deriv­a­tives : 2,3,4,6-Tetra-O-benzyl-D-galactopyranose, 2,3,4,6-Tetra-O- benzyl-D-mannopyranose
• Gly­co­syl halides : Ace­to­bro­mo-α-D-glu­cose, Ace­to­bro­mo-α-D-galac­tose, 2-Flu­o­ro-2- deoxy-D-glucose
• Car­bo­hy­drate-based drugs : Tribeno­side, Teni­po­side, Auranofin
• Oth­er : n-Octyl-β-D-glu­copy­ra­noside, n-Octyl-β-D-thioglu­copy­ra­noside, n-Dode­cyl-β-D-mal­to­side, 6-deoxy-D-glu­cose, Eth­yl-β-D-glu­curonide, 5-Thio-D-glucose

We also offer a range of 4-methy­lum­bel­lif­er­yl, nitro­phenyl, indolyl, naph­thyl and oth­er gly­cosi­dase substrates.

We can do

• Nat­ur­al nucleotides and mod­i­fied ana­logues, such as non-hydrolyz­able deriv­a­tives, nucleotides con­tain­ing flu­o­res­cent groups or halo­gen atoms and much more.
• Libraries of Nucleotide ana­logues for drug screen­ing and nucleotide kits for a pletho­ra of applications
• Mod­i­fied nucle­o­side ana­logues (i.e. nucle­obase linked to a sug­ar moi­ety but lack­ing the phos­phate groups)
• Phos­pho­ramidites used to syn­the­size oligonu­cleotides by auto­mat­ed stan­dard protocols

In addi­tion, with our pre-made build­ing blocks and in-house exper­tise we man­u­fac­ture even the most exot­ic nucleotide ana­logue from the mg to kg scale in a Cus­tom Synthesis.