Beta-Amyloid(25-35) CAS 131602-53-4

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• Prop­er­ties
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Iden­ti­fi­ca­tion

CAS Number

131602-53-4

Name

Beta-Amyloid(25-35)

Pep­tide sequence

Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Syn­onyms

131602-53-4 [RN]
amy­loid β-peptide(25-35)
Gly­­cyl-L-seryl-L-asparaginyl-L-lysyl­g­ly­­cyl-L-alanyl-L-isoleucyl-L-isoleucyl­g­ly­­cyl-L-leucyl-L-methion­in [Ger­man] [ACD/IUPAC Name]
Gly­­cyl-L-seryl-L-asparaginyl-L-lysyl­g­ly­­cyl-L-alanyl-L-isoleucyl-L-isoleucyl­g­ly­­cyl-L-leucyl-L-methio­n­ine [ACD/IUPAC Name]
Gly­­cyl-L-séryl-L-asparaginyl-L-lysyl­g­ly­­cyl-L-alanyl-L-isoleucyl-L-isoleucyl­g­ly­­cyl-L-leucyl-L-méthio­n­ine [French] [ACD/IUPAC Name]
L-Methio­n­ine, gly­­cyl-L-seryl-L-asparaginyl-L-lysyl­g­ly­­cyl-L-alanyl-L-isoleucyl-L-isoleucyl­g­ly­­cyl-L-leucyl- [ACD/​Index Name]
(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoic acid
[131602-53-4]
Å-Amy­loid (25-35)
Amy­loid b (25-35)
Amy­loid β-pep­tide (25-35) (human)
Amy­loid-�� Pep­tide (25-35), Human
Amy­loid β Pro­tein frag­ment 25-35
Amy­loid β-pep­tide (25-35) (human)
amy­loid β-pro­tein (25-35)
amy­loid β-pro­tein frag­ment 25-35
amyloidβpeptide(25-35),human
BU7435200
Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
L-Methionine,glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-
MFCD00133076
β-AMY­LOID (25-35)

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC­CN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CN

Std­InChI

InChI=1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-/m0/s1

Std­InChIKey

WIH­B­N­MPFWRHGDF-SLVFW­P­MISA-N

Mol­e­c­u­lar Formula

C₄₅H₈₁N₁₃O₁₄S

Mol­e­c­u­lar Weight

1060.27

MDL Number

MFCD00133076

Prop­er­ties

Appear­ance

White pow­der

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Beta-Amyloid(25-35) CAS 131602-53-4

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

98% min

Absorp­tion coefficient

0 M-1cm-1

PI,iso­elec­tric point

pH 10.12

Net charge at pH 7

1

Sol­u­bil­i­ty evaluation

Poor water solubility

Tox­i­c­i­ty mech­a­nism of Amy­loid oligomer

1. The effect on oxida­tive stress. Aβ can induce oxida­tive stress, pro­duce a large num­ber of free rad­i­cals, and then pro­duce oxida­tive stress on neurons.
2. Cause Ca2+ dis­or­der. Aβ destroys the K+ chan­nel on the cell mem­brane, caus­ing a large amount of Ca2+ influx.
3. Inter­ac­tion with recep­tors on the cell mem­brane sur­face. Amy­loid oligomers can acti­vate exci­ta­to­ry NMDA2RS recep­tors, caus­ing mito­chon­dr­i­al dis­or­ders and neu­ronal death.
4. Amy­loid in cells is also an impor­tant patho­log­i­cal fea­ture. A large num­ber of oligomers in the cells cause pathol­o­gy. The pro­duc­tion and degra­da­tion of Amy­loid secret­ed by nor­mal cells is rel­a­tive­ly balanced.
5. Break the bal­ance between Bax and Bel-2.

Shelf Life

2 years

Stor­age

Store at -20°C or -80°C for long time, Sealed and away from light

Known Appli­ca­tion

Often used to study Alzheimer’s disease.

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