BTB-1 CAS 86030-08-2

• Iden­ti­fi­ca­tion
• Prop­er­ties
• Safe­ty Data
• Spec­i­fi­ca­tions & Oth­er Information
• Links
• Quick Inquiry

Iden­ti­fi­ca­tion

CAS Number

86030-08-2

Name

BTB-1

Syn­onyms

4-Chlor-2-nitro-1-(phenylsulfonyl)benzol [Ger­man] [ACD/IUPAC Name]
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene [ACD/IUPAC Name]
4-Chloro-2-nitro-1-(phénylsulfonyl)benzène [French] [ACD/IUPAC Name]
4-Chloro-2-nitro­phenyl phenyl sul­fone
86030-08-2 [RN]
Ben­zene, 4-chloro-2-nitro-1-(phenylsulfonyl)- [ACD/​Index Name]
BTB-1
[86030-08-2] [RN]
1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid
1-(benzenesulfonyl)-4-chloro-2-nitrobenzene
1-Ben­zene­­sul­­fonyl-4-chloro-2-nitroben­zene
1-Ben­zene­­sul­­fonyl-4-chloro-2-nitro-ben­zene
2-Ben­zene­­sul­­fonyl-5-chloroni­troben­zene
4-chloro-2-nitro-1-(phenylsulfonyl)-benzene
4-Chloro-2-nitro-1-(phenylsulphonyl)benzene
4-Chloro-2-nitrodiphenyl sul­fone
4-Chloro-2-nitrodiphenyl sul­fone ; 1-(Benzenesulfonyl)-4-chloro-2-nitrobenzene
4-Chloro-2-nitrodiphenyl sul­phone
4-Chloro-2-nitrodiphenyl­­sul­­fone
87395-64-0 [RN]
BTB 1
BTB1
MFCD00052250 [MDL num­ber]
N-(1-Hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide
NSC 156750 ; NSC 658180
SS-5790

SMILES

c1ccc(cc1)S(=O)(=O)c2ccc(cc2[N+](=O)[O-])Cl

Std­InChI

InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H

Std­InChIKey

VZDUQPHKUBZMLW-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C₁₂H₈ClNO₄S

Mol­e­c­u­lar Weight

297.714

Prop­er­ties

Appear­ance

White to off-white

Struc­ture

Safe­ty Data

Sym­bol

Sig­nal Word

Warn­ing

WGK Germany

3

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Water

Loss on Drying

Residue on Ignition

Sin­gle Impurity

Total Impu­ri­ties

Shelf Life

2 years

Stor­age

store at room tem­per­a­ture away from light ; Sealed in dry.

Known Appli­ca­tion

BTB-1 CAS 86030-08-2 also called 4-CHLORO-2-NITRO-1-(PHENYL­SUL­FONYL)BEN­ZENE, is a selec­tive and ATP-com­pet­i­­tive mitot­ic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits micro­­tubule-stim­u­lat­ed Kif18A ATPase activ­i­ty. BTB-1 shows cell tox­i­c­i­ty with an EC50 val­ues of 35.8μM. HeLa cells treat­ed with 50μM BTB1 reveals severe defects inspin­dle mor­phol­o­gy and chro­mo­some alignment.Treatment with high con­cen­tra­tions of BTB-1 does not result in elon­gat­ed spindles.

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our R&D com­pa­ny Wat­son Bio Lim­it­ed (https://​www​.wat​son​-bio​.com/).

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly.