Col­is­timethate Sodi­um CAS 8068-37-9(8068-28-8)

Iden­ti­fi­ca­tion Prop­er­ties Safe­ty Data Spec­i­fi­ca­tions & Oth­er Information Links

Iden­ti­fi­ca­tion

CAS Number

8068-37-9(8068-28-8)

Name

Col­is­timethate Sodi­um

Syn­onyms

{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-Hydroxyéthyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatométhyl)amino]éthyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]ami no}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-méthyloctanoyl]amino}-4-[(sulfonatométhyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}méthanesulfonate de pen­ta­sodi­um [French] [ACD/IUPAC Name] 2,6,9,14-Tetraazapentadecane-1,15-disulfonic acid, 8-[(1R)-1-hydroxyethyl]-5-[[[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris[2-[( sulfomethyl)amino]ethyl]-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]-11-[[(6R)-6-methyl-1-oxooctyl]amino]-7,10-dioxo-, sodi­um salt, (5S,8S,11S)- (1:5) [ACD/​Index Name] col­istin A sodi­um methane­sul­fonate col­istin A sul­fomethate sodi­um Pen­tana­tri­um-{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotrico san-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methansulfonat [Ger­man] [ACD/IUPAC Name] Pen­ta­sodi­um {[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricos an-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonate [ACD/IUPAC Name] polymyx­in E1 sodi­um methane­sul­fonate 8068-28-8 [RN] clotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonate Col­is­timethate sodi­um col­istin A sul­fomethate sodi­umpolymyx­in E1 sodi­um methane­sul­fonatepolymyx­in E1 sul­fomethate sodi­um Col­istin X ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}-2-methyl-7,10,13-trioxo-19-sulfonato-9-{2-[(sulfonatomethyl)amino]ethyl}-8,11,14,18-tetraazanonadec-1-yl NOCAS_872303 pen­ta­sodi­um (2S,9S,12S,15S)-12-[(1R)-1-hydroxyethyl]-15-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino] pen­ta­sodi­um {[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacy pen­ta­sodi­um {[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfonatomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-{[(6R)-6-methyloctanoyl]amino}-4-[(sulfonatomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonate polymyx­in E1 sul­fomethate sodi­um

SMILES

CC[C@@H](C)CCC­CC(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCNCS(=O)(=O)[O-])C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCNCS(=O)(=O)[O-])CC(C)C)CC(C)C)CCNCS(=O)(=O)[O-])CCNCS(=O)(=O)[O-])[C@@H](C)O.[Na+].[Na+].[Na+].[Na+].[Na+]

Std­InChI

InChI=1S/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5/t35-,36-,37-,38+,39+,40+,41+,42+,43+,44+,45-,47+,48+;;;;;/m1…../s1

Std­InChIKey

IQWHCHZ­­FYP­IVRV-VLLYEMIK­SA-I

Mol­e­c­u­lar Formula

C58H105N16Na5O28S5

Mol­e­c­u­lar Weight

1749.81

EINECS

232-516-9

MDL Number

MFCD00130824

Prop­er­ties

Appear­ance

White to slight­ly yel­low, odor­less, fine pow­der

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

Eye­shields, Gloves, type N95 (US), type P1 (EN143) res­pi­ra­tor fil­ter

RIDADR

NONH for all modes of trans­port

WGK Germany

2 

RTECS

GH1650000

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Col­is­timethate Sodi­um CAS 8068-37-9(8068-28-8)

Stan­dard

USP

Iden­ti­fi­ca­tion Methods

IR

Assay(on the basis)

≥390ug/​mg

Bac­te­r­i­al endotoxins

≤2.0EU/​mg

Micro­bial limit

TMAC≤1000cfu/​g TYMC≤100cfu/​g

Heavy met­al

≤30ppm

Loss on Drying

≤7.0%

Free col­istin

No imme­di­ate pre­cip­i­tate in formed

pH

6.5-8.5

Pack­age

Accord­ing to cus­tomer require­ments to pack­ag­ing

Stor­age

Under the room tem­per­a­ture and away from light

Appli­ca­tion

Col­is­timethate sodi­um is one of the first choic­es for Pseudomonas aerug­i­nosa infec­tion. It can treat Pseudomonas aerug­i­nosa menin­gi­tis and can also be used for sep­sis, uri­nary sys­tem, abdomen and oth­er post-oper­a­­tive infec­tions.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​c​o​l​i​s​t​i​m​e​t​h​a​t​e​-​s​o​d​i​u​m​-​c​a​s​-​8​0​6​8​-​3​7​-​9​8​0​6​8​-​2​8​-8/

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