Dal­ba­vancin CAS 171500-79-1

• Iden­ti­fi­ca­tion
• Prop­er­ties
• Safe­ty Data
• Spec­i­fi­ca­tions & Oth­er Information
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Iden­ti­fi­ca­tion

CAS Number

171500-79-1

Name

Dal­ba­vancin

Syn­onyms

(1S,2R,19R,22R,34S,37R,40R,52S)-5,32-Dichlor-52-{[3-(dimethylamino)propyl]carbamoyl}-2,26,31,44,49-pentahydroxy-47-(α-D-mannopyranosyloxy)-22-(methylamino)-21,35,38,54,56,59-hexaoxo-7,13,28-trioxa -20,36,39,53,55,58-hexaazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8(64),9,11,14,16,23(61),24,26,29(60),30,32,41(57),42,44,46 ,48,50,62,65-henicosaen-64-yl-2-desoxy-2-[(1 [Ger­man] [ACD/IUPAC Name]
171500-79-1 [RN]
Acide 2-désoxy-2-[(10-méthylundecanoyl)amino]-β-D-glucopyranosiduronique de (1S,2R,19R,22R,34S,37R,40R,52S)-5,32-dichloro-52-{[3-(diméthylamino)propyl]carbamoyl}-2,26,31,44,49-pentahydroxy-47-(alph a-D-mannopyranosyloxy)-22-(méthylamino)-21,35,38,54,56,59-hexaoxo-7,13,28-trioxa-20,36,39,53,55,58-hexaazaundécacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046, 51]hexahexaconta-3,5,8(64),9,11,14,16,23(61 [French] [ACD/IUPAC Name]
B0U42518WL
Dal­ba­vancin [INN] [USAN] [Wiki]
BI 397
dal­ba­vancin B0
dal­ba­vancin hcl
Dal­vance [Trade name]
Dal­vance ;MDL-63397 ;BI-397
MDL-63397
UNII-808UI9M­S5K

SMILES

CC(C)CCC­C­C­C­C­CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1Oc2c3cc4cc2Oc5ccc(cc5Cl)[C@H]([C@H]6C(=O)N[C@@H](c7cc(cc(c7-c8cc(ccc8O)[C@H](C(=O)N6)NC(=O)[C@@H]4NC(=O)[C@@H]9c1cc(cc(c1Cl)O)Oc1cc(ccc1O)[C@H](C(=O)N[C@H](Cc1ccc(cc1)O3)C(=O)N9)NC)O[C@@H]1[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O)C(=O)NCC­CN(C)C)O)C(=O)O)O)O

Std­InChI

InChI=1S/C88H100Cl2N10O28/c1-38(2)13-10-8-6-7-9-11-14-61(106)94-70-73(109)75(111)78(86(120)121)128-87(70)127-77-58-31-43-32-59(77)124-55-24-19-42(29-50(55)89)71(107)69-85(119)98-67(80(114)92-25-12-26-100(4)5)48-33-44(102)34-57(125-88-76(112)74(110)72(108)60(37-101)126-88)62(48)47-28-40(17-22-52(47)103)65(82(116)99-69)95-83(117)66(43)96-84(118)68-49-35-46(36-54(105)63(49)90)123-56-30-41(18-23-53(56)104)64(91-3)81(115)93-51(79(113)97-68)27-39-15-20-45(122-58)21-16-39/h15-24,28-36,38,51,60,64-76,78,87-88,91,101-105,107-112H,6-14,25-27,37H2,1-5H3,(H,92,114)(H,93,115)(H,94,106)(H,95,117)(H,96,118)(H,97,113)(H,98,119)(H,99,116)(H,120,121)/t51-,60-,64-,65-,66-,67+,68+,69+,70-,71-,72-,73-,74+,75+,76+,78+,87-,88+/m1/s1

Std­InChIKey

KGPGQDLT­D­HGEGT-SZUN­QUCB­SA-N

Mol­e­c­u­lar Formula

C₈₈H₁₀₀Cl₂N₁₀O₂₈

Mol­e­c­u­lar Weight

1816.69

Prop­er­ties

Appear­ance

White to tan powder

Safe­ty Data

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Dal­ba­vancin CAS 171500-79-1

Iden­ti­fi­ca­tion Methods

HPLC

Puri­ty

98% min

Colour And Clar­i­ty Of Solu­tion (ChP)

The solu­tion is clear and not more intense­ly col­ored than ref­er­ence solu­tion Y4 or OY4. 

pH

20~3.0

Chlo­ride Ion 

2.4%~3.5%

Residue sol­vents

Methanol

≤0.3%

Ethanol

≤0.5%

Ace­tone

≤1.0%

Iso­propyl alcohol

≤0.5%

Ace­toni­trile

≤0.041%

N, N-dimethyl­­for­­mamide

≤0.088%

Water

10.0%~20.0%

Heavy Met­al

≤20ppm

Residue on Ignition

≤0.2%

Com­po­nent Dis­tri­b­u­tion(%AUC)

B0

≥80.0%

A0+A1

≤5.0%

B1+B2

≤8.0%

Relat­ed Sub­stances(%AUC)

MAG (RRT≈0.13)

≤3.0%

ISOB0 (RRT≈0.84)

≤1.5%

Any indi­vid­ual unknown impurity

≤0.2%

Total impu­ri­ties (except A0, A1, B1 and B2)

≤5.0%

Assay (On the anhy­drous Basis) 

85.0%~100.0%

Shelf Life

2 years

Stor­age

Store at -20℃ for long time ; Pre­serve in sealed in containers. 

Known Appli­ca­tion

Dal­ba­vancin is a new semi­syn­thet­ic gly­copep­tide antibi­ot­ic. It can effec­tive­ly inhib­it the cell wall biosyn­the­sis of G + bac­te­ria, and is wide­ly used as a med­i­cine for treat­ing skin and soft tis­sue infections.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​d​a​l​b​a​v​a​n​c​i​n​-​c​a​s​-​1​7​1​5​0​0​-​7​9​-1/

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