Structure of Pomalidomide CAS 19171-19-8

Iden­ti­fi­ca­tion

CAS Number

19171-19-8

Name

Poma­lido­mide

Syn­onyms

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
19171-19-8 [RN]
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)- [ACD/​Index Name]
3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindol-1,3(2H)-dion [Ger­man] [ACD/IUPAC Name]
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione [ACD/IUPAC Name]
4-Amino-2-(2,6-dioxo-3-pipéridinyl)-1H-isoindole-1,3(2H)-dione [French] [ACD/IUPAC Name]
4-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Actim­id
D2UX06XLB5
MFCD12756407 [MDL num­ber]
poma­lido­mi­da [Span­ish] [INN]
poma­lido­mide [French] [INN]
Poma­lido­mide [INN] [USAN] [Wiki]
POMA­LIDO­MIDE, (R)-
POMA­LIDO­MIDE, (S)-
poma­lido­midum [Latin] [INN]
Pom­a­lyst [Trade name]
UNII :D2UX06XLB5
(R)-pomalidomide
[19171-19-8] [RN]
1377838-49-7 [RN]
1H-Indol-7-ylmethanol [ACD/IUPAC Name]
202271-89-4 [RN]
202271-90-7 [RN]
2EE4M42K6G
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
443912-23-0 [RN]
443919-33-3 [RN]
4-amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
4-Amino-2-(2,6-dioxo-3-piperidyl) isoin­do­line -1,3-dione
4-amino-2-(2,6-dioxo-3-piperidyl)isoindole-1,3-dione
4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
4-Amino-2-(2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione
4-AMINO-2-(2,6-DIOXO-PIPERIDIN-3-YL)ISOIN­DOLE-1,3-DIONE
4-Aminothali­do­mide
Actimid,4-Aminothalidomide,CC 4047
CC4047
CC-4047;Actim­id ;CC4047 ;CC 4047
CC-4047|IMID-3|Imnovid®|Pomalyst®
D08976
DB08910
IMID-3
Imnovid
Imnovid (trade name)
Imnovid®
NR3397905
Phthal­im­ide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
poma­lido­mi­da
Poma­lido­mide (CC-4047)
Poma­lido­mide (JAN/USAN/INN)
pomalidomide(cc-4047,actimid)
Poma­li­do­mide-d5
poma­lido­midum
Pom­a­lyst (TN)
Pom­a­lyst®
помалидомид [Russ­ian]
بوماليدوميد [Ara­bic]
泊马度胺 [Chi­nese]

SMILES

c1cc2c(c(c1)N)C(=O)N(C2=O)C3CCC(=O)NC3=O

Std­InChI

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

Std­InChIKey

UVSMN­L­NDYGZF­PF-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C13H11N3O4

Mol­e­c­u­lar Weight

273.24

MDL Number

MFCD12756407

Prop­er­ties

Appear­ance

White pow­der

Safe­ty Data

RIDADR 

NONH for all modes of transport

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Poma­lido­mide CAS 19171-19-8

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

95% min

Stor­age

Store at 2-8℃ for long time.

Fea­tures

Sub­strate Pro­teins : The pri­ma­ry lig­ands for E3 lig­as­es are sub­strate pro­teins that need to be ubiq­ui­ti­nat­ed for degra­da­tion or reg­u­la­tion. These sub­strate pro­teins can vary wide­ly depend­ing on the spe­cif­ic E3 lig­ase and the cel­lu­lar process it regulates.

Ubiq­ui­tin : In the ubiq­ui­ti­na­tion process, ubiq­ui­tin itself acts as a lig­and. It forms a thioester bond with the active site cys­teine of the E3 lig­ase before being trans­ferred to the sub­strate protein.

Adap­tor Pro­teins : Some E3 lig­as­es require adap­tor pro­teins to facil­i­tate sub­strate recog­ni­tion and ubiq­ui­ti­na­tion. These adap­tor pro­teins can also act as lig­ands for the E3 ligase.

Small Mol­e­cules : In some cas­es, small mol­e­cules or chem­i­cal com­pounds can mod­u­late the activ­i­ty of E3 lig­as­es by bind­ing to them direct­ly or affect­ing their inter­ac­tions with oth­er proteins.

Post-tran­s­la­­tion­al Mod­i­fi­ca­tions (PTMs): PTMs of either the E3 lig­ase itself or its sub­strate pro­teins can also serve as lig­ands, reg­u­lat­ing the ubiq­ui­ti­na­tion process.

Over­all, the lig­ands for E3 lig­as­es play cru­cial roles in sub­strate recog­ni­tion, ubiq­ui­tin trans­fer, and the reg­u­la­tion of cel­lu­lar processes.

Known Appli­ca­tion

Sub­strate Recog­ni­tion : Lig­ands facil­i­tate the recog­ni­tion of spe­cif­ic sub­strate pro­teins by E3 lig­as­es. These lig­ands can be pro­tein motifs, post-tran­s­la­­tion­al mod­i­fi­ca­tions (such as phos­pho­ry­la­tion or acety­la­tion), or adap­tor pro­teins that bring sub­strates to the E3 ligase.

Ubiq­ui­ti­na­tion : Once a sub­strate is rec­og­nized, E3 lig­as­es cat­alyze the trans­fer of ubiq­ui­tin mol­e­cules to the sub­strate pro­tein. These lig­ands are cru­cial for facil­i­tat­ing the trans­fer of ubiq­ui­tin from the E2 ubiq­ui­tin-con­ju­­gat­ing enzyme to the substrate.

Reg­u­la­tion of Pro­tein Sta­bil­i­ty : Ubiq­ui­ti­na­tion medi­at­ed by E3 lig­as­es marks sub­strate pro­teins for degra­da­tion by the pro­tea­some. Lig­ands for E3 lig­as­es thus reg­u­late the sta­bil­i­ty of pro­teins in the cell by tar­get­ing them for degradation.

Reg­u­la­tion of Pro­tein Func­tion : Ubiq­ui­ti­na­tion can also reg­u­late the activ­i­ty, local­iza­tion, or inter­ac­tion part­ners of sub­strate pro­teins with­out lead­ing to degra­da­tion. Lig­ands for E3 lig­as­es are involved in this reg­u­la­to­ry process by con­trol­ling the extent and site of ubiquitination.

Cel­lu­lar Sig­nal­ing : Ubiq­ui­ti­na­tion medi­at­ed by E3 lig­as­es is involved in var­i­ous cel­lu­lar sig­nal­ing path­ways, includ­ing those reg­u­lat­ing cell cycle pro­gres­sion, DNA repair, immune response, and apop­to­sis. Lig­ands for E3 lig­as­es mod­u­late these sig­nal­ing path­ways by tar­get­ing spe­cif­ic pro­teins for ubiquitination.

Over­all, lig­ands for E3 lig­as­es are essen­tial for sub­strate recog­ni­tion, ubiq­ui­ti­na­tion, and the reg­u­la­tion of pro­tein sta­bil­i­ty and func­tion, there­by influ­enc­ing numer­ous cel­lu­lar process­es and sig­nal­ing pathways.

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd (https://​www​.cam​ing​.com/).

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