Thalido­mide CAS 50-35-1

• Iden­ti­fi­ca­tion
• Prop­er­ties
• Safe­ty Data
• Spec­i­fi­ca­tions & Oth­er Information
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Iden­ti­fi­ca­tion

CAS Number

50-35-1

Name

Thalido­mide CAS 50-35-1

Syn­onyms

Thalido­mide
(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
(±)-Thalido­mide
(±)-Thalido­mide
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- [ACD/​Index Name]
2-(2,6-Dioxo-3-piperidinyl)-1H-isoindol-1,3(2H)-dion [Ger­man] [ACD/IUPAC Name]
2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione [ACD/IUPAC Name]
2-(2,6-Dioxo-3-pipéridinyl)-1H-isoindole-1,3(2H)-dione [French] [ACD/IUPAC Name]
2-(2,6-Dioxopiperidin-3-yl)-1H-isoindol-1,3(2H)-dion
2-(2,6-Dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
2-(2,6-dioxopipéridin-3-yl)-1H-isoindole-1,3(2H)-dione
200-031-1 [EINECS]
4Z8R6ORS6L
50-35-1 [RN]
5-22-13-00224 [Beil­stein]
Con­ter­gan [Wiki]
MFCD00153873 [MDL num­ber]
Neose­dyn
Neosy­dyn
Neu­ro­dyn
Softenon [Wiki]
Tal­ido­mi­da [Span­ish] [INN]
Tal­ido­mide [DCIT]
thalido­mide [French] [INN]
THALIDO­MIDE, (R)-
THALIDO­MIDE, (S)-
Thalido­midum [Latin] [INN]
Thalo­mide
TI4375000
UNII :4Z8R6ORS6L
талидомид [Russ­ian] [INN]
ثاليدوميد [Ara­bic] [INN]
沙利度胺 [Chi­nese] [INN]
Telargan
(��)-Thalido­mide
(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
(±)-N-(2,6-dioxo-3-piperidyl)phthalimide
(±)-N-(2,6-Dioxo-3-piperidyl)phthalimide
(±)-N-(2,6-dioxo-3-piperidyl)phthalimide ; (±)-thalido­mide ; 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline ; 2,6-dioxo-3-phthalimidopiperidine ; N-(2,6-dioxo-3-piperidyl)phthalimide ; N-Phthaloyl­glu­­tamimide ; N-Phtha­­lyl­glu­­tam­ic acid imide ; Pro-ban M ; α-(N-phthalimido)glutarimide ; α-N-phtha­­lyl­glu­­taramide ; α-phthal­im­i­­dog­lu­­tarim­ide
(±)-Thalido­mide
(±)-Thalido­mide – CAS 50-35-1 – Cal­biochem
(R)-(+)-Thalidomide
(R,S)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
(S)-(−)-Thalidomide
1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline
1219177-18-0 [RN]
14088-68-7 [RN]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (R)-
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-, (S)-
2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
2-(2,6-dioxoazaperhydroin-3-yl)benzo[c]azoline-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
2-(6-hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
2,6-Dioxo-3-phthalimidopiperidine
2-[(3S)-2,6-dioxo-3-piperidinyl]isoindole-1,3-dione
200-031-1MFCD00153873
2614-06-4 [RN]
2-phthal­im­i­­dog­lu­­tarim­ide
3-Phthal­im­i­­dog­lu­­tarim­ide
6160-65-2 [RN]
731-40-8 [RN]
Actim­id
Algose­div
a-Phthal­im­i­­dog­lu­­tarim­ide
Asi­don 3
Asma­dion
Asmaval
Bon­brain
Cal­more
Cal­morex
Con­ter­gan (Trade name)
Con­ter­gan ; Dis­taval ; K-17 ; Sedalis ; Softenon ; Tal­imol ; Thaled
Cor­ronaro­betin
D013792
Dis­taval
Dis­taval (Trade name)
Dis­taval ; K-17 ; Sedalis ; Softenon ; Tal­imol
Dis­tax­al
Dis­to­val
Ectil­u­ran
Enterose­div
Gas­trinide
Glu­pan
Glu­tanon
Glu­tarim­ide, 2-phthal­im­i­­do-
Grippex
Hip­pu­zon
https://​www​.ebi​.ac​.uk/​c​h​e​m​b​l​/​c​o​m​p​o​u​n​d​r​e​p​o​r​t​c​a​r​d​/​C​H​E​M​B​L​4​68/
Imi­­da-lab
Imi­dan
Imi­dan (pey­ta)
Imi­dene
Isomin
K-17 (Trade name)
Kedavon
Kevadon
l-Thali­do­mide
Lulamin
N-(2,6-dioxo-3-piperidinyl)phthalimide
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-(2,6-Dioxopiperidin-3-yl)phthalimide
Nea­u­fatin
NEO
Nerose­dyn
Neu­fatin
Neu­rosedin
Neu­rosedym
Neu­rose­dyn
Nevro­dyn
Nibrol
Noc­tose­div
Nox­o­dyn
N-Phthal­im­i­­dog­lu­­tam­ic acid imide
N-Phthaloyl­glu­­tamimide
N-Phtha­­lyl­glu­­tam­ic acid imide
N-Phtha­­lyl-glu­t­a­min­saeure-imid [Ger­man]
N-Phtha­­lyl-glu­t­a­min­saeure-imid
OR-1446
Pan­gul
Pan­tose­div
Phar­­makon1600-01503607
Pharmion
Phthal­im­ide, N-(2,6-dioxo-3-piperidyl)-
Pitu­itary Adeny­late Cyclase-Acti­­vat­ing Polypep­tide 1-38 |
Pred­ni-sediv
Pro-Bam M
Pro-ban M
Pro­farmil
Psy­choliq­uid
Psy­chotablets
Que­timid
Qui­eto­plex
rac-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
San­dormin
Sedalis
Sedalis (Trade name)
Sedalis sedi-lab
Sed­imide
Sedin
Sedis­per­il
Sedoval
Shin-naito S
Shin­ni­brol
Sleep­an
Slipro
Soft­e­nil
Softenon (Trade name)
Suaramide
Syn­ovir
Talargan
tal­ido­mi­da
tal­ido­mi­da ; thalido­mide ; thalido­midum
TAL­IMOL
Tal­imol (Trade name)
Tal­i­nol
Tal­is­mol
Tal­iz­er
Tela­gan
Telargean
Ten­si­val
Thaled
Thaled (TN)
Thalido­mide (JAN/USP/INN)
Thalidomide;N-(2,6-Dioxopiperidin-3-yl)phthalimide
thalido­midum
Thalin
Tha­linette
Thalo­mid [Wiki]
Theophil­choline
Ulcer­fen [Trade name]
Val­gis
Val­graine
WLN : T56 BVN­VJ C- DT6VMVTJ
WLN : T56 BVN­VJ C- DT6VMVTJ -D
WLN : T56 BVN­VJ C- DT6VMVTJ -L
Yodomin
α-(N-phthalimido)glutarimide
α-(N-Phthalimido)glutarimide
α-(N-Phthalimido)glutarimide
α-N-phtha­­lyl­glu­­taramide
α-N-Phtha­­lyl­glu­­taramide
α-N-Phtha­­lyl­glu­­taramide
α-phthal­im­i­­dog­lu­­tarim­ide
α-Phthal­im­i­­dog­lu­­tarim­ide
α-Phthal­im­i­­dog­lu­­tarim­ide
талидомид
ثاليدوميد
沙利度胺

SMILES

c1ccc2c(c1)C(=O)N(C2=O)C3CCC(=NC3=O)O

Std­InChI

InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

Std­InChIKey

UEJJHQ­­NACJXSKW-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C₁₃H₁₀N₂O₄

Mol­e­c­u­lar Weight

258.229

EINECS

200-031-1

Beil­stein Reg­istry Number

5-22-13-00224

MDL Number

MFCD00153873

Prop­er­ties

Appear­ance

White pow­der

Safe­ty Data

RIDADR 

NONH for all modes of transport

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Thalido­mide CAS 50-35-1

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

95% min

Stor­age

Store at 2-8℃ for long time.

Fea­tures

Sub­strate Pro­teins : The pri­ma­ry lig­ands for E3 lig­as­es are sub­strate pro­teins that need to be ubiq­ui­ti­nat­ed for degra­da­tion or reg­u­la­tion. These sub­strate pro­teins can vary wide­ly depend­ing on the spe­cif­ic E3 lig­ase and the cel­lu­lar process it regulates.

Ubiq­ui­tin : In the ubiq­ui­ti­na­tion process, ubiq­ui­tin itself acts as a lig­and. It forms a thioester bond with the active site cys­teine of the E3 lig­ase before being trans­ferred to the sub­strate protein.

Adap­tor Pro­teins : Some E3 lig­as­es require adap­tor pro­teins to facil­i­tate sub­strate recog­ni­tion and ubiq­ui­ti­na­tion. These adap­tor pro­teins can also act as lig­ands for the E3 ligase.

Small Mol­e­cules : In some cas­es, small mol­e­cules or chem­i­cal com­pounds can mod­u­late the activ­i­ty of E3 lig­as­es by bind­ing to them direct­ly or affect­ing their inter­ac­tions with oth­er proteins.

Post-tran­s­la­­tion­al Mod­i­fi­ca­tions (PTMs): PTMs of either the E3 lig­ase itself or its sub­strate pro­teins can also serve as lig­ands, reg­u­lat­ing the ubiq­ui­ti­na­tion process.

Over­all, the lig­ands for E3 lig­as­es play cru­cial roles in sub­strate recog­ni­tion, ubiq­ui­tin trans­fer, and the reg­u­la­tion of cel­lu­lar processes.

Known Appli­ca­tion

Sub­strate Recog­ni­tion : Lig­ands facil­i­tate the recog­ni­tion of spe­cif­ic sub­strate pro­teins by E3 lig­as­es. These lig­ands can be pro­tein motifs, post-tran­s­la­­tion­al mod­i­fi­ca­tions (such as phos­pho­ry­la­tion or acety­la­tion), or adap­tor pro­teins that bring sub­strates to the E3 ligase.

Ubiq­ui­ti­na­tion : Once a sub­strate is rec­og­nized, E3 lig­as­es cat­alyze the trans­fer of ubiq­ui­tin mol­e­cules to the sub­strate pro­tein. These lig­ands are cru­cial for facil­i­tat­ing the trans­fer of ubiq­ui­tin from the E2 ubiq­ui­tin-con­ju­­gat­ing enzyme to the substrate.

Reg­u­la­tion of Pro­tein Sta­bil­i­ty : Ubiq­ui­ti­na­tion medi­at­ed by E3 lig­as­es marks sub­strate pro­teins for degra­da­tion by the pro­tea­some. Lig­ands for E3 lig­as­es thus reg­u­late the sta­bil­i­ty of pro­teins in the cell by tar­get­ing them for degradation.

Reg­u­la­tion of Pro­tein Func­tion : Ubiq­ui­ti­na­tion can also reg­u­late the activ­i­ty, local­iza­tion, or inter­ac­tion part­ners of sub­strate pro­teins with­out lead­ing to degra­da­tion. Lig­ands for E3 lig­as­es are involved in this reg­u­la­to­ry process by con­trol­ling the extent and site of ubiquitination.

Cel­lu­lar Sig­nal­ing : Ubiq­ui­ti­na­tion medi­at­ed by E3 lig­as­es is involved in var­i­ous cel­lu­lar sig­nal­ing path­ways, includ­ing those reg­u­lat­ing cell cycle pro­gres­sion, DNA repair, immune response, and apop­to­sis. Lig­ands for E3 lig­as­es mod­u­late these sig­nal­ing path­ways by tar­get­ing spe­cif­ic pro­teins for ubiquitination.

Over­all, lig­ands for E3 lig­as­es are essen­tial for sub­strate recog­ni­tion, ubiq­ui­ti­na­tion, and the reg­u­la­tion of pro­tein sta­bil­i­ty and func­tion, there­by influ­enc­ing numer­ous cel­lu­lar process­es and sig­nal­ing pathways.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd (https://​www​.cam​ing​.com/).

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