Prostaglandins are the most common and first line agents for lowering intraocular pressure. Prostaglandin agents were introduced in the United States in 1996 and soon became common and popular due to their potency, safe systemic side effect profile and once daily dosing. Three most common prostaglandin analogs are available in the United States. They include : bimatoprost, latanoprost and travoprost. Prostaglandins reduce the intraocular pressure by increasing the outflow of aqueous mostly by enhancing the oveoscleral pathway. They do not have an effect on aqueous production. It is believed that prostaglandins improve the uveoscleral pathway by altering the ciliary body and sclera architecture. This makes it more amenable to aquous egress through stimulation of collagenases and matrix metallproteinases and the relaxation of ciliary muscle bundles.
Pros of Prostaglandins
Prostaglandins are the most potent typical agents for lowering intraocular pressure. Prostaglandins possess the highest peak mean difference from baseline intraocular pressure as compared to any other class of topical antiglaucoma agent. The relative change from mean baseline at peak is 31 to 33 percent. All three analogs, travoprost, bimatoprost and latanoprost possess the same efficacy. However, individual patients may respond different to drugs within this class. Additionally, prostaglandin analogs have not shown any significant measurable side effects, but the fact remains that some people experience a few minor adverse effects to this drug. According to recent researches, bimatoprost and travoprost are effective for cosmetic use as well. They have been found to promote eyelash growth. Bimatoprost and travoprost eye drops, when used, thicken the eyelashes ; however, it is advised that these eye drops are applied on the upper eyelashes only. Also, being new analogs, they do not degenerate ; thus, can be sold in large quantities as well. It should always be made sure that these eye drops are not utilized more than once a day. Always consult your doctor before using any of these eye drops. Inform him/her of any allergies you suffer from and the medication you take daily. If you’re looking for any of these glaucoma effective analogs, get in touch with our team. We, at
Watson International, ensure that all your unique needs are met. We also offer chemicals such as cyclohexanediaminetetraacetic acid,
undecylenoyl glycine and numerous others.