10-DAB semisynthetic paclitaxel CAS 33069-62-4

10-DAB semisynthetic paclitaxel CAS 33069-62-4

Identification

CAS Number

33069-62-4

Name

10-DAB semisynthetic paclitaxel

Synonyms

(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,9-dihydroxy-15-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-ylbenzolcarboxylat
(2a,5b,7b,10b,13a)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
(2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate [ACD/IUPAC Name]
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl-benzoat [German] [ACD/IUPAC Name]
33069-62-4 [RN]
5b,20-Epoxy-1,2a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine
Anzatax [Trade name]
benzenepropanoic acid, b-(benzoylamino)-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13
,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- [ACD/Index Name]
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
Benzoate de (2α,5β,7β,10β,13α)-4,10-diacétoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phénylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-époxytax-11-én-2-yle [French] [ACD/IUPAC Name]
BMS 181339-01
Ebetaxel [Trade name]
LipoPac [Trade name]
Onxol [Trade name]
paclitaxel [Spanish] [INN]
paclitaxel [French] [INN]
Paclitaxel [BAN] [INN] [USAN] [Wiki]
paclitaxelum [Latin] [INN]
Paxceed [Trade name]
Paxene
Peclitaxel
Plaxicel [Trade name]
TaxAlbin
Taxol [Trade name]
Taxol A
UNII-P88XT4IS4D
Yewtaxan
паклитаксел [Russian] [INN]
باكليتاكسال [Arabic] [INN]
紫杉醇 [Chinese] [INN]
cyclopax
(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
(2aR-(2aα,4β,4aβ,6β,9α(α R,βS),11α,12α,12bα))-β-(Benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-(benzoylamino)-a-hydroxybenzenepropanoate
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl diacetate
4α,10β-bis(acetyloxy)-13α-[(2S,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyloxy]-1,7β-dihydroxy-9-oxo-5β,20-epoxytax-11-en-2α-yl benzoate
5β,20-Epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
ACon1_002231
Benzenepropanoic acid, β-(benzoylamino)- α-hydroxy-, 6,12b-bis(acetyl oxy)-12-(benzoyloxy)- 2a,3,4,4a,5,6,9,10,11,12,12a,12b,- dodecahydro-4,11- dihydroxy-4a,8,13,13-tetramethyl-5-oxo- 7,11-methano- 1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR- [2aα,4β,4aβ,6β,9α(α. R,βS),11α,12α,12aα,12bα]]-
BMS-181339-01
BPBio1_000320
BSPBio_000290
cMAP_000068
DA8340700
DHP-107
DHP-208
Genaxol
Genetaxyl
Genexol
Genexol-PM
Intaxel
MEGxp0_001940
MFCD00869953 [MDL number]
Mitotax
Nanotaxel
OAS-PAC-100
OncoGel
Onxol; Paxceed
Paclical
Pacligel
Paxceed (Trade name)
Paxene (Trade name)
Paxoral
Prestwick3_000155
STOCK1N-71343
TA1
Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β, 10β,13α- hexahydroxy-, 4,10-diacetate 2- benzoate,13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α- hexahydroxy-, 4,10-diacetate 2-benzoate, 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine (8CI)
Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine (8CI)
Taxol®
Taxol; Taxol A
Xorane

SMILES

CC1=C2[email protected]C)(C[[email protected]@H]1OC(=O)[email protected]@Hc6ccccc6)O)O)OC(=O)c7ccccc7)(CO4)OC(=O)C)O)C)OC(=O)C

StdInChI

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

StdInChIKey

RCINICONZNJXQF-MZXODVADSA-N

Molecular Formula

C47H51NO14

Molecular Weight

853.92

Beilstein Registry Number

1420457

MDL Number

MFCD00869953

Properties

Appearance

White to off-white powder

Safety Data

Symbol

exclamation-mark-jpgexclamation-mark-jpgexclamation-mark-jpgGHS05, GHS07

Signal Word

Danger

Hazard statements

H315-H317-H318-H334-H335-H341-H361-H371

Precautionary Statements

P260-P280-P305 + P351 + P338-P342 + P311

Personal Protective Equipment

Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges and purpose. It may be toxic or hazardous, and should be handled only by qualified individuals trained in laboratory procedures. The buyer will be responsible to warn and inform any person that may be in contact with the product of the potential risks and hazards, as well as to ensure that purchase, use and disposal of the product comply with local laws and regulations.

RIDADR 

UN 3224A1 4.1 / PGII

WGK Germany

3

RTECS

DA8340700

Specifications and Other Information of Our 10-DAB semisynthetic paclitaxel CAS 33069-62-4

Identification Methods

HPLC

Purity

99%~101%

Related substance

1.2%max

IO-Deacetyl-baccatin III

0.10%max

Baccatin III

0.2%max

Photodegradant

0.1%max

10-Deacctyl paclitaxel

0.2%max

2-Debenzoylpaclitaxcl-2-pentenoate

0.7%max

Oxelanenng opened,acetyl and benzoyl migrated

0.4%max

10-Acetoacetylpaclitaxel

0.4%max

10-Deacetyl-7-epi paclitaxel

0.4%max

7-Epipaclitaxel(E)

0.4%max

10,13-Bissidechain paclitaxel

0.4%max

7-Acetylpaclitaxel

0.5%max

13-Tes-baccatin III

0.1%max

7-Tes-paclitaxel

0.2%max

Others

0.1%max of each

Residual Solvents

Total

1490 ug/g max

Dichloromethane

60 ug/g max

n-Butanol

100 ug/g max

Acetone

1000 ug/g max

Petroleum ether

100 ug/g max

Moisture

3.0%max

Heavy Metals

0.002% max

Bacterial Endotoxins

Max 0.3EU/mg Paclitaxel

Total aerobic microbial

Max 50cfu/g Paclitaxel

Staphaureus, Pseudomonas aeruginosa, Salmonella species and E.Coli

Meet the requirements

Residue on Ignition

0.2%max

Fungi

Max 10cfu/g Paclitaxel

Shelf Life

3 years

Storage

Under room temperature away from light

Productivity

800kg/year

Known Application

It is an anti-tumor medicinal plants, for ovarian cancer, breast cancer and the like.

This product is developed by our R&D company Caming Pharmaceutical Ltd(http://www.caming.com/), and here is the corresponding linkhttp://www.caming.com/10-dab-semisynthetic-paclitaxel-cas-33069-62-4/

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly (Please change screen to horizontal for complete browsing if you are checking Watson on your mobile phone).
* indicates required field