(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE CAS 110351-94-5

Iden­ti­fi­ca­tion Prop­er­ties Safe­ty Data Spec­i­fi­ca­tions andamp ; Oth­er Information Links

Iden­ti­fi­ca­tion

CAS Number

110351-94-5

Name

(S)-4-ETHYL-4-HYDROXY-7,8-DIHY­DRO-1H-PYRA­NO[3,4-F]INDOLIZINE-3,6,10(4H)-TRI­ONE

Syn­onyms

(4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizin-3,6,10(4H)-tri­on [Ger­man] [ACD/IUPAC Name] (4S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-tri­one [ACD/IUPAC Name] (4S)-4-Éthyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-tri­one [French] [ACD/IUPAC Name] (s)-8-Ethyl-8-hydroxy-2,3,5,8-tetrahydro-6-oxa-3a-aza-cyclopenta[b]naphthalene-1,4,7-trione 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-tri­one, 4-ethyl-7,8-dihydro-4-hydroxy-, (4S)- [ACD/​Index Name] (4S)-4-ETH­YL-4-HYDROXY-1H,3H,4H,6H,7H,8H,10H-PYRA­NO[3,4-F]INDOLIZINE-3,6,10-TRI­ONE (4S)-4-ETH­YL-4-HYDROXY-1H,7H,8H-PYRA­NO[3,4-F]INDOLIZINE-3,6,10-TRI­ONE (4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione (4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-tri­one (S)-4-ETHYL-4-HYDROXY-7,8-DIHY­DRO-1H-PYRA­NO[3,4-F]INDOLIZINE-3,6,10(4H)-TRI­ONE (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3 (S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-tri­one [110351-94-5] 110351-94-5 [RN] 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-, (4S)- ANW-72103 CTK4A6861 IGK­­WOG­M­­VAOYVSJ-ZDUSS­CGK­SA-N MFCD09833229 MFCD17011873 [MDL num­ber] Mol­­Port-005-933-313 SCHEMBL614060 ZINC01616399

Mol­e­c­u­lar Structure

SMILES

CC[C@@]1(c2cc3n(c(=O)c2COC1=O)CCC3=O)O

Std­InChI

InChI=1S/C13H13NO5/c1-2-13(18)8-5-9-10(15)3-4-14(9)11(16)7(8)6-19-12(13)17/h5,18H,2-4,6H2,1H3/t13-/m0/s1

Std­InChIKey

IGK­­WOG­M­­VAOYVSJ-ZDUSS­CGK­SA-N

Mol­e­c­u­lar Formula

C13H13NO5

Mol­e­c­u­lar Weight

263.246

MDL Number

MFCD17011873

Prop­er­ties

Appear­ance

Light yel­low sol­id

Melt­ing Point

185℃

Safe­ty Data

Sig­nal Word

Warn­ing

WGK Germany

3 

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our (S)-4-ETHYL-4-HYDROXY-7,8-DIHY­DRO-1H-PYRA­NO[3,4-F]INDOLIZINE-3,6,10(4H)-TRI­ONE CAS 110351-94-5

Stan­dard

Enter­prise stan­dard

Iden­ti­fi­ca­tion Methods

HNMR,HPLC

Puri­ty

95%min

Spe­cif­ic Opti­cal Rotation

+76°~+78° (c 0.62, CHCl3)

Stor­age

Pre­served in tight con­tain­ers

Appli­ca­tion

It is the key inter­me­di­ate for the syn­the­sis of a series of (20S)-camp­tothecin ana­logues. Since its iso­la­tion from the Chi­nese plant Camp­tothe­caacumi­na­ta by Wall et al. In 1966, (20S)-camp­tothecin, a pent acyclic nat­ur­al alka­loid, has re-emerged as one of the most impor­tant lead com­pounds for the dis­cov­ery of new and selec­tive anti­cancer drugs because of the dis­clo­sure of its unique mech­a­nism of action as a selec­tive inhibitor DNA topoi­so­merase Ⅰ, a process caus­ing irre­versible DNA dam­age and sub­se­quent cell death. Three camp­tothecin deriv­a­tives with high anti­tu­mor activ­i­ty, topote­can, belote­can, and irinote­can, have been launched as anti­cancer drugs in clin­i­cal prac­tice, and many oth­er ana­logues are at var­i­ous stages of clin­i­cal devel­op­ment.

Gen­er­al View of Documents

andnb­sp ;

Links

This prod­uct is devel­oped by our RD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​s​-​4​-​e​t​h​y​l​-​4​-​h​y​d​r​o​x​y​-​7​8​-​d​i​h​y​d​r​o​-​1​h​-​p​y​r​a​n​o​3​4​-​f​i​n​d​o​l​i​z​i​n​e​-​3​6​1​0​4​h​-​t​r​i​o​n​e​-​c​a​s​-​1​1​0​3​5​1​-​9​4​-5/

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you short­ly (Please change screen to hor­i­zon­tal for com­plete brows­ing if you are check­ing Wat­son on your mobile phone).