5-(Tetradecyloxy)-2-furoic acid (TOFA) CAS 54857-86-2

• Iden­ti­fi­ca­tion
• Prop­er­ties
• Safe­ty Data
• Spec­i­fi­ca­tions & Oth­er Information
• Links
• Quick Inquiry

Iden­ti­fi­ca­tion

CAS Number

54857-86-2

Name

5-(Tetradecyloxy)-2-furoic acid (TOFA)

Syn­onyms

2-Furan­­car­boxylic acid, 5-(tetradecyloxy)- [ACD/​Index Name]
5-(Tetradecyloxy)-2-furoesäure [Ger­man] [ACD/IUPAC Name]
5-(Tetradecyloxy)-2-furoic acid [ACD/IUPAC Name]
5-(tetradecyloxy)furan-2-carboxylic acid
54857-86-2 [RN]
Acide 5-(tétradécyloxy)-2-furoïque [French] [ACD/IUPAC Name]
MFCD01726059 [MDL num­ber]
OLUMA­CO­STAT
TOFA
[54857-86-2]
5- (tetradecyloxy)-2-furoic acid
5-(tetradecyloxy)-2-furancarboxylic acid
539681
5659-20-1 [RN]
5-tetrade­­coxy­­fu­ran-2-car­boxylic acid
5-Tetrade­­cy­loxy-2-furon­ic acid
92047-08-0 [RN]
CAR­DIODI­LATIN
https://​www​.ebi​.ac​.uk/​c​h​e​b​i​/​s​e​a​r​c​h​I​d​.​d​o​?​c​h​e​b​i​I​d​=​C​H​E​B​I​:​7​7​936
RMI-14514
SS-4313
TOFA – CAS 54857-86-2 – Cal­biochem
TOFA (5-(Tetradecyloxy)-2-furoic acid)
tofa (rmi14514;mdl14514)
TOFA, RMI 14514

SMILES

CCCCCCCCCCCCCCOc1ccc(o1)C(=O)O

Std­InChI

InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)

Std­InChIKey

CZR­C­­FAOMWRAF­IC-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C₁₉H₃₂O₄

Mol­e­c­u­lar Weight

324.45

MDL Number

MFCD01726059

Prop­er­ties

Appear­ance

White to beige powder

Melt­ing Point

112~115°C

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

dust mask type N95 (US), Eye­shields, Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

2

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 5-(Tetradecyloxy)-2-furoic acid (TOFA) CAS 54857-86-2

Iden­ti­fi­ca­tion Methods

HNMR, MS, HPLC

Puri­ty

97.5%min

Solubility(2mg/ml,DMSO)

Clear

Shelf Life

2 years

Stor­age

Store at 2-5℃, keep in dry and aovid direct sun light.

Known Appli­ca­tion

TOFA has been used as a lipid biosyn­the­sis inhibitor in mes­enchy­mal stro­mal cells (MSCs), human pluripo­tent stem cells., an acetyl-CoA car­boxy­lase 1 inhibitor in murine adipocyte cell lines., a lipol­y­sis inhibitor in can­cer stem cells (CSCs). TOFA has been used as an ACC inhibitor to study its effect on insulin secre­tion in INS-1E cells TOFA is a cell-per­me­able, potent, reversible, and com­pet­i­tive inhibitor of acetyl-CoA car­boxy­lase (ACC). TOFA is a key enzyme involved in fat­ty acid biosyn­the­sis. TOFA inhibits cel­lu­lar fat­ty acid syn­the­sis in a dose-depen­­dent man­ner (IC50 = 4 μM in human breast can­cer cell line MCF7)

Gen­er­al View of Documents

Links

This prod­uct is devel­oped by our R&D com­pa­ny Wat­son Bio Ltd (https://​www​.wat​son​-bio​.com/).

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly.