Curcumin(Natural) CAS 458-37-7

• Identification
• Properties
• Safety Data
• Specifications & Other Information
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Identification

CAS Number

458-37-7

Name

Curcumin(Natural)

Synonyms

Curcumin (Tautomeric form) [REDIRECT]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-on [German] [ACD/IUPAC Name]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one [ACD/IUPAC Name]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-méthoxyphényl)-1,4,6-heptatrién-3-one [French] [ACD/IUPAC Name]
(1E,4Z,6E)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one
1,4,6-Heptatrien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,4Z,6E)- [ACD/Index Name]
Curcumin [Wiki]
IN00142
(1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one
(1z,4z,6e)-5-Hydroxy-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)hepta-1,4,6-Trien-3-One
115851-80-4 [RN]
458-37-7 [RN]
5-HYDROXY-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTA-1,4,6-TRIEN-3-ONE
CUR
Curcu
Curcumin (Diferuloylmethane)
diferuloylmethane
Diferuloylmethane, Natural Yellow 3, C.I. 75300
Diferuloylmethane;Natural Yellow 3;C.I. 75300
GOLDEN SEAL HYDRASTIS CANADENSIS EXT.
Kacha haldi
Natural yellow 3
Tumeric

SMILES

COc1cc(ccc1O)/C=C/C(=C/C(=O)/C=C/c2ccc(c(c2)OC)O)/O

StdInChI

InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-

StdInChIKey

ZIUSSTSXXLLKKK-KOBPDPAPSA-N

Molecular Formula

C₂₁H₂₀O₆

Molecular Weight

368.38

EINECS

207-280-5

Beilstein Registry Number

2306965

MDL Number

MFCD00008365

Properties

Appearance

Brownish-yellow to Orange-yellow Powder

Safety Data

RIDADR 

NONH for all modes of transport

WGK Germany

3

RTECS 

MI5230000

Specifications and Other Information of Our Curcumin(Natural) CAS 458-37-7

Identification Methods

HPLC

Total Crucuminoide (by HPLC)

≥95%

Loss on Drying

≤1.0%

Heavy Metals

≤10ppm

Pb

<2.0ppm

As

<2.0ppm

Hg

<1.0ppm

Cd

<1.0ppm

Total Plate Count

<3000cfu/g

Yeast & Mold

<300cfu/g

E.Coli

Non-detective

Salmonella

Non-detective

Shelf Life

2 years

Storage

Store in cool and dry place, away from light.

Known Application

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) ac tivity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase. Inhibits inducible nit ric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nucle ar envelope. Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease.

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