structure of dorzolamideHydrochloride CAS 130693 82 2 - Dorzolamide Hydrochloride CAS 130693-82-2

Iden­ti­fi­ca­tion

CAS Number

130693-82-2

Name

Dor­zo­lamide Hydrochloride

Syn­onyms

(4S,6S) 7,7-Dioxyde de 4-(éthylamino)-6-méthyl-5,6-dihydro-4H-thiéno[2,3-b]thiopyrane-2-sulfonamide, chlorhy­drate (1:1) [French] [ACD/IUPAC Name]
(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide, mono­hy­drochlo­ride
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamid-7,7-dioxidhydrochlorid
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamid-7,7-dioxidhydrochlorid (1:1) [Ger­man] [ACD/IUPAC Name]
(4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochlo­ride
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochlo­ride (1:1) [ACD/IUPAC Name]
(4S,6S)-4-(éthylamino)-6-méthyl-5,6-dihydro-4H-thiéno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxyde chlorhy­drate
120279-96-1 [RN]
130693-82-2 [RN]
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-, hydrochlo­ride (1:1) [ACD/​Index Name]
4H-thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-, mono­hy­drochlo­ride
Dor­zo­lamide (hydrochlo­ride)
Dor­zo­lamide HCl
Dor­zo­lamide hydrochlo­ride
MFCD00884659 [MDL num­ber]
(2S,4S)-2-Ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide hydrochlo­ride
(2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-thiopheno[3,2-e]thiin-6-sulfonamide, chlo­ride
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide 4H-Thieno[2,3-b]thiopyran-2-sulfonamide hydrochlo­ride
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, hydrochlo­ride
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4HH-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide mono­hy­drochlo­ride
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, mono­hy­drochlo­ride
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide hydrochlo­ride
(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochlo­ride
(SS,6S)-N-ethyl-6-methyl-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-aminium 7,7-dioxide chlo­ride
[130693-82-2] [RN]
120279-36-9 [RN]
Dorza­lamide hydrochlo­ride
Dor­zo­lamide [Wiki]
Dor­zolo­mide hydrochlo­ride
eth­yl-[(4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-yl]azanium and chlo­ride
Hydrochlo­ride
KS-1348
L671152 hydrochlo­ride
L671152 hydrochlo­ride ;MK507 hydrochloride;Trusopt hydrochlo­ride
MK507 hydrochlo­ride
Tru­sopt [Trade name] [Wiki]
Tru­sopt hydrochlo­ride
Tru­sopt, Cosopt

SMILES

CCN[C@H]1C[C@@H](S(=O)(=O)c2c1cc(s2)S(=O)(=O)N)C.Cl

Std­InChI

InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1

Std­InChIKey

OSRUS­F­P­M­RGD­LAG-QMGYSKNISA-N

Mol­e­c­u­lar Formula

C10H17ClN2O4S3

Mol­e­c­u­lar Weight

360.901

EINECS

620-304-2

Beil­stein Reg­istry Number

5896026

MDL Number

MFCD00884659

Prop­er­ties

Appear­ance

A white to off white c1ystalline powder.

Safe­ty Data

Sym­bol

exclamation mark jpg - Dorzolamide Hydrochloride CAS 130693-82-2health hazard jpg - Dorzolamide Hydrochloride CAS 130693-82-2GHS07, GHS08

Sig­nal Word

Warn­ing

Haz­ard statements

H302 – H373

Pre­cau­tion­ary Statements

P260 – P264 – P270 – P301 + P312 – P314 – P501

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

a) I. R : IR Spec­trum of sam­ple should con­cor­dant with IR Spec­trum ofDor­zo­lamide hydrochlo­ride WS.
b) HPLC : The reten­tion time of the major peak in the chro­ma to gr扣n of the assay prepa­ra­tion
c) Chlo­ride tes : prepa­ra­tion as obtained in the assay. A white ore­cioi­tate should form.

Assay

99% min

Heavy Met­als

NMT IO ppm

Water

NMT0.5 %

Lim­it ofDor­zo­lamide Hydrochlo­ride Relat­ed com­pound A (By HPLC)

NMT0.5%

Residue on Ignition

NMT0.1 %

Resid­ual solvent

Ace­tone

NMT 5000 ppm

Iso­propyl alcohol

NMT 5000 ppm

Eth­yl acetate

NMT 5000 ppm

Tetrahy­dro­fu­ran

NMT720 ppm

Any indi­vid­ual Impurity

NMT 0.1 %

Total Impu­ri­ties

NMT 0.5%

Shelf Life

2 years

Stor­age

Under room tem­per­a­ture away from light

Pro­duc­tiv­i­ty

1MT/​month

Known Appli­ca­tion

Dor­zo­lamide Hydrochlo­ride is a car­bon­ic anhy­drase inhibitor. Dor­zo­lamide hydrochlo­ride is an anti-glau­­co­­ma top­i­cal eye drops. Dor­zo­lamide hydrochlo­ride is used to reduce the increased intraoc­u­lar pres­sure in open angle glau­co­ma and ocu­lar hypertension

Gen­er­al View of Documents

This prod­uct is devel­oped by our R&D com­pa­ny Wat­son­noke Sci­en­tif­ic Lim­it­ed (http://​www​.wat​son​noke​.com/).

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