Lev­o­folin­ic acid CAS 68538-85-2

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Iden­ti­fi­ca­tion

CAS Number

68538-85-2

Name

Lev­o­folin­ic acid

Syn­onyms

(6S)-5-formyl­te­trahy­dro­folic acid
68538-85-2 [RN]
Acide N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-ptéridinyl]méthyl}amino)benzoyl]-L-glutamique [French] [ACD/IUPAC Name]
Lev­oleu­cov­orin
L-Folin­ic acid
L-Glu­­tam­ic acid, N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]- [ACD/​Index Name]
N-[4-({[(6S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]-L-glutamic acid [ACD/IUPAC Name]
N-[4-({[(6S)-2-Amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl]methyl}amino)benzoyl]-L-glutaminsäure [Ger­man] [ACD/IUPAC Name]
(2S)-2-[[[4-[[(6R)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioic acid
(2S)-2-[[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]-oxomethyl]amino]pentanedioic acid
(2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-keto-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]glutaric acid
(2S)-2-[[4-[[(6R)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
(2S)-2-[[4-[[(6R)-2-amino-5-methanoyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioic acid
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-keto-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]glutaric acid
(2S)-2-[[4-[[(6S)-2-AMINO-5-FORMYL-4-OXO-1,6,7,8-TETRAHY­DROPTERIDIN-6- YL]METHY­LAMINO]BEN­ZOYL]AMINO]PEN­TANE­DIOIC ACID
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioic acid
(2S)-2-[[4-[[(6S)-2-amino-5-methanoyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioic acid
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid
(6R,S)-5-Formyltetrahydrofolate
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid
(6S)-5-Formyl-5,6,7,8-tetrahydrofolic acid ; (6S)-5-formyl­te­trahy­dro­folic acid ; (6S)-Folin­ic acid ; (6S)-Leu­cov­orin ; (S)-Leucovorin ; Cit­ro­vo­rum fac­tor ; L-Folin­ic acid ; Lev­o­fo­lene ; Lev­o­folin­ic acid ; N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
(6S)-5-formyl­te­trahy­dro­fo­late
(6S)-5-HCO-H4fo­late
(6S)-Folin­ic acid
(6S)-Leu­cov­orin
(S)-Leucovorin
[(6S)-5-formyl-5,6,7,8-tetrahydropteroyl]glutamate
10-formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
121451-09-0 [RN]
1492-18-8 [RN]
200-361-6 [EINECS]
58-05-9 [RN]
5-CHO-H4PteGlu1
5-FORMYL-5,6,7,8-TETRAHY­DRO­FO­LATE
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-FORMYL-6-HYDRO­­FOLIC ACID
5-Formyl­te­­trahy­­dro­­fo­late
5-formyl­te­­trahy­­dro­­folic acid
5-Formyl­te­­trahy­­dropteroyl­glu­­ta­­mate
5-Formyl­te­­trahy­­dropteroyl­glu­­tam­ic acid
6R-Leu­­cov­­orin
73951-54-9 [RN]
Antiane­mia fac­tor
Apo-folic
Cit­ro­vo­rum fac­tor
Cit­ro­vo­rum fac­tor ; Folin­ic acid ; L-leu­­cov­­orin ; Lev­oleu­cov­orin
FFO
foli­nate [Wiki]
folin­ic acid [INN] [Wiki]
Folin­ic acid cal­ci­um salt
Folin­ic acid-SF
Fusilev
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
Leu­cal
Leu­cov­orin [USAN]
Lev­o­fo­lene
Lev­o­folin­ic acid
L-Glu­­tam­ic acid, N-(4-((((6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
L-Glu­­tam­ic acid, N-(4-((((6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
L-Glu­­tam­ic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, (S)-
L-leu­­cov­­orin
Mis­sion Pre­na­tal
Mittafol
MVC PLUS
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-D-Glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
n5-formyl­te­­trahy­­dro­­fo­late
N5-Formyl­te­­trahy­­dro­­folic acid
Nifolin
Novo­fo­lacid
Novo-folacid
N-Pteroyl-D-glu­­tam­ic acid
Pteroyl-D-glu­­ta­­mate
Pteroyl-D-glu­­tam­ic acid
Pteroyl­monog­lu­ta­mate
UNII-Q573I9D­VLP
Uzel [Trade name]
Uzel (Trade name)
Uzel ; Well­cov­orin
Vit­a­min B11
VITAPED
Wel­cov­orin
Well­cov­orin [Trade name]

SMILES

c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC[C@H]2CNc3c(c(=O)nc([nH]3)N)N2C=O

Std­InChI

InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

Std­InChIKey

VVI­AG­P­KUTFN­R­­DU-STQMWFEESA-N

Mol­e­c­u­lar Formula

C₂₀H₂₃N₇O₇

Mol­e­c­u­lar Weight

473.439

EINECS

200-361-6

Prop­er­ties

Appear­ance

Yel­low­ish to yel­low pow­der, odorless

Safe­ty Data

RIDADR 

NONH for all modes of transport

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Lev­o­folin­ic acid CAS 68538-85-2

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Assay

97.0% – 102.0% on the anhy­drous basis

Hygro­scop­ic­i­ty

< 0.2%

Spe­cif­ic Opti­cal Rotation

-11° to -16°

pH

3.5-4.5

Clar­i­ty

Solu­tion should be clarity

Chlo­rides

≤ 0.5%

D-Leu­­cov­­orin

≤ 0.5%

Heavy Met­als

≤ 20ppm

Water

≤ 2.0%

Residue on Ignition

≤ 0.5%

Relat­ed Sub­stances (I)

Impu­ri­ty A

≤ 0.2%

Impu­ri­ty E

≤ 0.2%

Impu­ri­ty F

≤ 0.2%

Oth­er sin­gle impurity

≤ 0.2%

Total Impu­ri­ties

≤ 1.5%

Relat­ed Sub­stances (II)

ZYG03≤ 0.6%

Ca

≤ 0.1%

Bac­te­r­i­al Endotoxin

< 1.0EU/​mg

Micro­bial Limit

TAMC

≤ 1000cfu/​g

TYMC

≤ 100cfu/​g

E. Coli.

Absent in 1g

Shelf Life

2 years

Stor­age

Store at room tem­per­a­ture, sealed and away from light.

Known Appli­ca­tion

Com­mon­ly used as impu­ri­ty reference.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd (https://​www​.cam​ing​.com/).

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