sds page 101 17F 3 - Recombinant Human Interleukin-17F (rHuIL-17F) CAS 101-176-1816

Offi­cial Full Name

Recom­bi­nant Human Inter­leukin-17F (rHuIL-17F)

CAS Num­ber (Or Wat­son Num­ber for Non-CAS Products)

101-176-1816

Syn­onyms

ML-1, IL-24

Squence

region 101 17F 1 - Recombinant Human Interleukin-17F (rHuIL-17F) CAS 101-176-1816

Amino Acid Sequence

MRKIP­KVGHT FFQKPESCPP VPG­GSMKL­DI GIINEN­QRVS MSRNIESRST SPWNYTVTWD PNRYP­SEVVQ AQCRNL­GCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVT­PVI HHVQ

Syn­onyms

ML-1, IL-24

Acces­sion

Q96PD4

Gene ID

112744

Sum­ma­ry

Human Inter­leukin-17F (IL-17F) is encod­ed by the IL17F gene locat­ed on the chro­mo­some 6 and belongs to the IL-17 fam­i­ly which con­tains IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17F that shares 50 % homol­o­gous of crys­tal struc­ture to IL-17A and is expressed by acti­vat­ed T cells, has the func­tions of stim­u­lat­ing pro­duc­tion of oth­er cytokines (such as IL-6, IL-8 and gran­u­lo­cyte colony-stim­u­lat­ing fac­tor) and pro­lif­er­a­tion of PBMC and T-cell, reg­u­lat­ing car­ti­lage matrix turnover, and inhibit­ing angio­gen­e­sis.

Source

Escherichia coli.

Mol­e­c­u­lar Weight

Approx­i­mate­ly 30.1 kDa, a disul­­fide-linked homod­imer of two 134 amino acid polypep­tide chains.

Bio­log­i­cal Activity

Ful­ly bio­log­i­cal­ly active when com­pared to stan­dard. The ED50 as deter­mined by induc­ing IL-6 secre­tion of murine NIH/3T3 cells is less than 20 ng/​ml, cor­re­spond­ing to a spe­cif­ic activ­i­ty of > 5.0 × 104 IU/​mg.

Appear­ance

Ster­ile fil­tered white lyophilized (freeze-dried) pow­der.

For­mu­la­tion

Lyophilized from a 0.2 um fil­tered con­cen­trat­ed solu­tion in PBS, pH 7.4.

Endo­tox­in

Less than 1 EU/​ug of rHuIL-17F as deter­mined by LAL method.

Recon­sti­tu­tion

We rec­om­mend that this vial be briefly cen­trifuged pri­or to open­ing to bring the con­tents to the bot­tom. Recon­sti­tute in 6 mM HCl to a con­cen­tra­tion of 0.1mg/ml. Stock solu­tions should be appor­tioned into work­ing aliquots and stored at ≤ -20 °C. Fur­ther dilu­tions should be made in appro­pri­ate buffered solu­tions.

Sta­bil­i­ty and Storage

Use a man­u­al defrost freez­er and avoid repeat­ed freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as sup­plied.- 1 month, 2 to 8 °C under ster­ile con­di­tions after recon­sti­tu­tion.- 3 months, -20 to -70 °C under ster­ile con­di­tions after recon­sti­tu­tion.

Ref­er­ences

1. Mungall AJ, Palmer SA, Sims SK, et al. 2003. Nature 425 : 805-11.2. Kolls JK, Lin­den A. 2004. Immu­ni­ty 21 : 467-76.3. Hymowitz SG, Fil­varoff EH, Yin JP, et al. 2001. EMBO J 20 : 5332-41.4. Starnes T, Robert­son MJ, Sledge G, et al. 2001. J Immunol 167 : 4137-40.

Puri­ty

> 95 % by SDS-PAGE and HPLC analy­ses.

SDS-PAGE

sds page 101 17F 2 - Recombinant Human Interleukin-17F (rHuIL-17F) CAS 101-176-1816

Pack Size

5ug/​100ug/​500ug

Safe­ty Data Sheet (SDS) Down­load

Click to download

Tech­ni­cal Data Sheet (TDS) Down­load

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Links

This prod­uct is brand­ed by ChemWhat and sold through our web­site and here is the cor­re­spond­ing link Recom­bi­nant Human Inter­leukin-17F (rHuIL-17F) on ChemWhat

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