IGF-1 CAS 67763-96-6

Iden­ti­fi­ca­tion

Name

IGF-1

CAS Number

67763-96-6, 61461-67-4

Syn­onyms

Insulin-Like Growth Fac­­tor-I, Human Insulin Growth Fac­­tor-I, Human SM-C Somatomedin 1 IGF-A, Human Sul­fa­tion Fac­tor C Myotrophin rhIGF-I Insulin-likegrowth fac­tor I 

Mol­e­c­u­lar Structure

MDL Number

MFCD00081716

Prop­er­ties

Appear­ance

Lyophilized Pow­der

Recom­bi­nant

Expressed in E. coli

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

Eye­shields, Gloves, type N95 (US), type P1 (EN143) res­pi­ra­tor fil­ter

WGK Germany

3 

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our IGF-1 CAS 67763-96-6

Vol­ume

1±0.1mg/vial

Con­cen­tra­tion

1.01mg/ml

Spe­cif­ic Activity

80000IU/​mg

Iden­ti­fi­ca­tion Methods

Elec­trophore­sis, HPLC

Puri­ty

97%

Impu­ri­ty Peak(10.1’)

1.5%

Impu­ri­ty Peak(11.3’)

1.5%

Steril­i­ty

Ster­ile-fil­tered

Endo­tox­in

4EU/​mg

Relat­ed Substances

1% max

Analy­sis Note

The bio­log­i­cal activiy is cal­cu­lat­ed by the dose-depen­­dent pro­lif­er­a­tion of murine BALB/C3T3 cells. ED50 cor­re­sponds to a spe­cif­ic activ­i­ty of at least 1 x 107 units/​mg.

Recon­sti­tu­tion

Recon­sti­tute in water.

Phys­i­cal Form

Lyophilized from 0.2 μm fil­tered solu­tion in 50 mM acetic acid.

Biochem/​physiol Actions

IGF-1 belongs to the insulin-like growth fac­tor fam­i­ly of sig­nal­ing mol­e­cules that play crit­i­cal roles in cel­lu­lar ener­gy metab­o­lism and in growth and devel­op­ment, espe­cial­ly pre­na­tal growth.Also known as somatomedin C, is secret­ed from the liv­er into cir­cu­la­tion in a process reg­u­lat­ed by pitu­itary growth hor­mone (GH) and so it medi­ates the growth-pro­­mot­ing activ­i­ty of GH. In the devel­op­ing embryo IGF-I is expressed pri­mar­i­ly by mes­enchy­­mal-derived cells. After birth IGF-I expres­sion in most extra­hep­at­ic tis­sues declines and hepat­ic expres­sion of it becomes GH-reg­u­lat­ed. Expres­sion of IGF-I out­side the liv­er is reg­u­lat­ed dif­fer­ent­ly, depend­ing on the spe­cif­ic tis­sues. For exam­ple, gonadotropins and sex steroids reg­u­late IGF-I expres­sion with­in the repro­duc­tive sys­tem, while parathy­roid hor­mone and sex steroids reg­u­late IGF-I expres­sion in bone. It is pro­duced in sev­er­al human tumors. It is mito­genic for a vari­ety of cells includ­ing fibrob­lasts, osteoblasts, smooth mus­cle cells, fetal brain cells, neu­roglial cells, and ery­throid prog­en­i­tor cells. IGF-I exerts its actions exclu­sive­ly through the IGF-I recep­tor (IGF-IR). it induces endothe­lial cell migra­tion and is involved in the reg­u­la­tion of angio­gen­e­sis. Also known as somatomedin C, is secret­ed from the liv­er into cir­cu­la­tion in a process reg­u­lat­ed by pitu­itary growth hor­mone (GH) and so it medi­ates the growth-pro­­mot­ing activ­i­ty of GH. In the devel­op­ing embryo it is expressed pri­mar­i­ly by mes­enchy­­mal-derived cells. After birth IGF-I expres­sion in most extra­hep­at­ic tis­sues declines and hepat­ic expres­sion of it becomes GH-reg­u­lat­ed. Expres­sion of IGF-I out­side the liv­er is reg­u­lat­ed dif­fer­ent­ly, depend­ing on the spe­cif­ic tis­sues. For exam­ple, gonadotropins and sex steroids reg­u­late IGF-I expres­sion with­in the repro­duc­tive sys­tem, while parathy­roid hor­mone and sex steroids reg­u­late IGF-I expres­sion in bone. It is pro­duced in sev­er­al human tumors. IGF-I is mito­genic for a vari­ety of cells includ­ing fibrob­lasts, osteoblasts, smooth mus­cle cells, fetal brain cells, neu­roglial cells, and ery­throid prog­en­i­tor cells. It exerts its actions exclu­sive­ly through the IGF-I recep­tor (IGF-IR). It induces endothe­lial cell migra­tion and is involved in the reg­u­la­tion of angio­gen­e­sis.

Gen­er­al View of Doccuments

Stor­age

−20°C

Wat­­son-Int Link

http://​wat​son​-int​.com/​I​G​F​-​1​_​C​A​S​_​6​7​7​6​3​-​9​6​-​6​.​h​tml