Trimetho­prim CAS 738-70-5

• Iden­ti­fi­ca­tion
• Prop­er­ties
• Safe­ty Data
• Spec­i­fi­ca­tions & Oth­er Information
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Iden­ti­fi­ca­tion

CAS Number

738-70-5

Name

Trimetho­prim

Syn­onyms

2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]- [ACD/​Index Name]
212-006-2 [EINECS]
5-(3,4,5-Trimethoxybenzyl)-2,4-pyrimidindiamin [Ger­man] [ACD/IUPAC Name]
5-(3,4,5-Trimethoxybenzyl)-2,4-pyrimidinediamine [ACD/IUPAC Name]
5-(3,4,5-Triméthoxybenzyl)-2,4-pyrimidinediamine [French] [ACD/IUPAC Name]
5-(3,4,5-Trimethoxybenzyl)pyrimidin-2,4-diamin [Ger­man]
5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine
5-(3,4,5-triméthoxybenzyl)pyrimidine-2,4-diamine [French]
5-{[3,4,5-tris(methyloxy)phenyl]methyl}pyrimidine-2,4-diamine
625127 [Beil­stein]
738-70-5 [RN]
Insta­lac [Trade name]
MFCD00036761 [MDL num­ber]
Monotrim [Trade name]
Pro­lo­prim [Trade name]
Syraprim [Trade name]
TCMDC-125538
Tiempe [Trade name]
Tri­manyl [Trade name]
Trimetho­prim [BAN] [INN] [JAN] [USAN] [Wiki]
Trimetho­prime [French]
Trimetho­pri­mum [Latin]
Trime­to­prim [Pol­ish]
Trime­to­pri­ma [Span­ish]
Tri­mo­gal [Trade name]
Tri­mopan [Trade name]
Trimpex [Trade name]
Triprim [Trade name]
Ure­trim [Trade name]
UV8225000
WELL­CO­PRIM [Trade name]
триметоприм [Russ­ian] [INN]
ثلاثي ميثوبريم [Ara­bic] [INN]
甲氧苄啶 [Chi­nese] [INN]
Abacin [Trade name]
Alprim
Bactin
Bak­tar [Trade name]
Chemotrim
Comox
Cotrim D.S.
Drylin [Trade name]
eusaprim [Trade name]
Fectrim [Trade name]
Gan­taprim
Gantrim [Trade name]
Idotrim
Imex­im [Trade name]
Kepinol [Trade name]
Laratrim [Trade name]
Linaris [Trade name]
Metho­prim
Microtrim [Trade name]
Nopil [Trade name]
Oraprim
Prilo­prim
Pri­mosept
Prim­sol
Sep­trin [Trade name]
Sigaprim [Trade name]
Sul­fotrim [Trade name]
Sul­prim [Trade name]
Sumetrolim [Trade name]
Supra­com­bin [Trade name]
Suprim [Trade name]
Teleprim [Trade name]
Thiocu­ran [Trade name]
Tmp-Ratio­pharm
Trigonyl [Trade name]
Trime­sulf [Trade name]
Trime­thio­prim
Trimetho­pri­om
Trimex­a­zole
Uni­trim
Uro­plus
Uro-Sep­­tra
[2-amino-5-(3,4,5-trimethoxybenzyl)pyrimidin-4-yl]amine
1-(2,3,4-Trimethoxybenzyl)piperazine [ACD/IUPAC Name]
1189460-62-5 [RN]
2,4-Diamino-5-(3′,4′,5′-trimethoxybenzyl)-pyrimidi
2,4-Diamino-5-(3′,4′,5′-trimethoxybenzyl)-p

SMILES

COc1cc(cc(c1OC)OC)Cc2c[nH]c(=N)[nH]c2=N

Std­InChI

InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

Std­InChIKey

IED­VJHCEM­CR­BQM-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C₁₄H₁₈N₄O₃

Mol­e­c­u­lar Weight

290.318

EINECS

212-006-2

Beil­stein Reg­istry Number

625127

MDL Number

MFCD00036761

Prop­er­ties

Appear­ance

White Spec­i­fi­ca­tions or yel­low­ish white powder

Melt­ing Point

Between 199-203°C

Safe­ty Data

Sym­bol

GHS06, GHS08

Sig­nal Word

Dan­ger

Haz­ard statements

Pre­cau­tion­ary Statements

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our 

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Infrared Absorp­tion Spectrophotometry

The infrared absorp­tion spec­turm of sam­ple is con­cor­dant with the spec­trum of trimetho­prim RS

Ultra­vi­o­let Visible

Cal­cu­late absorp­tiv­i­ties, on the dried basis for the at test sam­ple only, at the wave length of max­i­mum absorbance at about 287 min do not dif­fer by MT 3%

Puri­ty

98% min

Loss on Drying

NMT 0.5% w/​w

Residue on Ignition

NMT 0.1% w/​w

Sin­gle Impurity

Impu­ri­ty-A

NMT 0.1% w/​w

Impu­ri­­ty-B

NMT 0.1% w/​w

Impu­ri­­ty-C

NMT 0.1% w/​w

Impu­ri­­ty-D

NMT 0.1% w/​w

Impu­ri­­ty-E

NMT 0.1% w/​w

Impu­ri­­ty-F

NMT 0.1% w/​w

Impu­ri­­ty-G

NMT 0.1% w/​w

Impu­ri­­ty-J

NMT 0.1% w/​w

Impu­ri­­ty-K by GC

NMT 5ppm

Total Impu­ri­ties

NMT 0.2% w/​w

Shelf Life

5 years

Stor­age

Under room tem­per­a­ture away from light

Known Appli­ca­tion

Trimetho­prim is a lipophilic weak­ly basic pyrimethamine bac­te­rio­sta­t­ic agent, also known as sul­fa syn­er­gist, trimetho­prim, antibac­te­r­i­al syn­er­gist, trimetho­prim, trimetho­prim, trimetho­prim Ometho­prim, trimetho­prim, white or off-white crys­talline pow­der at room tem­per­a­ture, odor­less, bit­ter, slight­ly sol­u­ble in chlo­ro­form, slight­ly sol­u­ble in ethanol or ace­tone, almost insol­u­ble in water, eas­i­ly sol­u­ble in glacial acetic acid dis­solve. The antibac­te­r­i­al spec­trum is sim­i­lar to that of sul­fa drugs, but the antibac­te­r­i­al effect is stronger. It is effec­tive against Escherichia coli, Pro­teus mirabilis, Kleb­siel­la pneu­mo­ni­ae, Staphy­lo­coc­cus sapro­phyti­cus Chem­i­cal­book, and var­i­ous Gram-pos­i­­tive and neg­a­tive bac­te­ria, but it is inef­fec­tive against Pseudomonas aerug­i­nosa infec­tion and has the low­est antibac­te­r­i­al effect The con­cen­tra­tion is usu­al­ly low­er than 10mg/​L, and it is easy to cause bac­te­r­i­al resis­tance when used alone. There­fore, it is gen­er­al­ly not used alone. It is main­ly com­posed of com­pound prepa­ra­tions with sul­fon­amides. It is clin­i­cal­ly used to treat uri­nary tract infec­tions, intesti­nal infec­tions, res­pi­ra­to­ry infec­tions, bacil­lary dysen­tery, Enteri­tis, typhoid fever, menin­gi­tis, oti­tis media, menin­gi­tis, sep­sis and soft tis­sue infec­tion. The cura­tive effect on typhoid and paraty­phoid is not low­er than that of ampi­cillin, and it can also be used in com­bi­na­tion with long-act­ing sul­fa drugs for the pre­ven­tion and treat­ment of drug-resis­­tant fal­ci­parum malaria.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Lim­it­ed (http://​www​.cam​ing​.com/).

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