Halofug­i­none CAS 55837-20-2

Iden­ti­fi­ca­tion Prop­er­ties Safe­ty Data Spec­i­fi­ca­tions Links

Iden­ti­fi­ca­tion

CAS Number

55837-20-2

Mol­e­c­u­lar Structure

Name

Halofug­i­none

Syn­onyms

4(3H)-Quina­zoli­none, 7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]- [ACD/​Index Name] 7-Brom-6-chlor-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-chi­na­zoli­non [Ger­man] [ACD/IUPAC Name] 7-Bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quina­zoli­none [ACD/IUPAC Name] 7-Bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxy-2-pipéridinyl]-2-oxopropyl}-4(3H)-quina­zoli­none [French] [ACD/IUPAC Name] 7-Bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one 7-bro­­mo-6-chlo­ro­febrifug­ine Halofug­i­none stenorol 7-Bromo-6-chloro-3-[3-((2RS,3SR)-3-hydroxy-piperidin-2-yl)-2-oxo-propyl]-3H-quinazolin-4-one 7-Bromo-6-chloro-3-[3-((2S,3R)-3-hydroxy-piperidin-2-yl)-2-oxo-propyl]-3H-quinazolin-4-one empo­statin Halofug­i­non 17395-31-2(Halofuginone Hydro­bro­mide) 64924-67-0(Halofuginone Hydro­bro­mide) 55837-20-2(halofuginone) 1217623-74-9(Halofuginone hydrochlo­ride)

SMILES

c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)C[C@H]3[C@@H](CCCN3)O

Std­InChI

InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/m0/s1

Std­InChIKey

LVASCWIM­­LIKXLA-LSD­H­HAIUSA-N

Mol­e­c­u­lar Formula

C16H17BrClN3O3

Mol­e­c­u­lar Weight

414.68

Prop­er­ties

Appear­ance

White or off-white pow­der

Safe­ty Data

Sym­bol

GHS06, GHS09

Sig­nal Word

Dan­ger

Haz­ard Statements

H300 + H310 + H330-H315-H319-H410

Pre­cau­tion­ary Statements

Miss­ing Phrase – N15.00950417-P260-P280-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338

RIDADR

UN2811 – class 6.1 – PG 1 – EHS – Tox­ic solids, organ­ic, n.o.s., HI : all

WGK Germany

3 

RTECS

VA2397066

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Halofug­i­none CAS 55837-20-2

Puri­ty

99.0% min

Iden­ti­fi­ca­tion

HNMR,HPLC

Stor­age

Under room tem­per­a­ture and away from light

Use

Halofug­i­none is a coc­cidio­stat used in vet­eri­nary med­i­cine. It is a syn­thet­ic halo­genat­ed deriv­a­tive of febrifug­ine, a nat­ur­al quina­zoli­none alka­loid which can be found in the Chi­nese herb Dichroa febrifu­ga (Chang Shan).Collgard Bio­phar­ma­ceu­ti­cals is devel­op­ing halofug­i­none for the treat­ment of scle­ro­der­ma and it has received orphan drug des­ig­na­tion from the U.S. Food and Drug Admin­is­tra­tion. Halofug­i­none inhibits the devel­op­ment of T helper 17 cells, immune cells that play an impor­tant role in autoim­mune dis­ease, but it does not affect oth­er kinds of T cells which are involved in nor­mal immune function.Halofuginone there­fore has poten­tial for the treat­ment of autoim­mune dis­or­ders. Halofug­i­none is also an inhibitor of col­la­gen type I gene expres­sion and as a con­se­quence it may inhib­it tumor cell growth.Halofuginone exerts its effects by act­ing as a high affin­i­ty inhibitor of the enzyme Glu­­tamyl-Pro­­lyl tRNA syn­thetase. Inhi­bi­tion of pro­lyl tRNA charg­ing leads to the accu­mu­la­tion of uncharged pro­lyl tRNAs, which serve as a sig­nal to ini­ti­ate the amino acid star­va­tion response, which in turn exerts anti-inflam­­ma­­to­ry and anti-fibrot­ic effects.

Links

Cam­ing Link

This prod­uct is devel­oped by our RD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd (http://​cam​ing​.com/), focus­ing on API andamp ; Inter­me­di­ate Tech­nol­o­gy and here is the cor­re­spond­ing link in Cam­ing http://​cam​ing​.com/​h​a​l​o​f​u​g​i​n​o​n​e​-​c​a​s​-​5​5​8​3​7​-​2​0​-2/

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