Halofug­i­none Hydro­bro­mide CAS 17395-31-2(64924-67-0)

Iden­ti­fi­ca­tion
Prop­er­ties
Safe­ty Data
Spec­i­fi­ca­tions
Links

Iden­ti­fi­ca­tion

CAS Number

17395-31-2
64924-67-0

Mol­e­c­u­lar Structure

struc­ture of Halofug­i­none Hydro­bro­mide CAS 17395-31-2

Name

Halofug­i­none Hydrobromide

Syn­onyms

(±)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quina­zoli­none mono­hy­dro­bro­mide
(±)-trans-7-Bromo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quina­zoli­none hydro­bro­mide
4(3H)-Quina­zoli­none, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydro­bro­mide, trans-(±)-
4(3H)-Quina­zoli­none, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, hydro­bro­mide (1:1)
7-Brom-6-chlor-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-chi­na­zoli­non­hy­dro­bro­mid (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quina­zoli­none hydro­bro­mide (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-pipéridinyl)-2-oxopropyl]-4(3H)-quina­zoli­none, bromhy­drate (1:1)
4(3H)-Quina­zoli­none, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, mono­hy­dro­bro­mide
4(3H)-Quina­zoli­none, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)acetonyl)-, mono­hy­dro­bro­mide
7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-2-oxopropyl)quinazolin-4(3H)-one mono­hy­dro­bro­mide
7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3H)-one mono­hy­dro­bro­mide
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide
17395-31-2
64924-67-0
55837-20-2(halofuginone)
1217623-74-9(Halofuginone hydrochlo­ride)

SMILES

c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)CC3C(CCCN3)O.Br

Std­InChI

InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2 ;1H

Std­InChIKey

SJUWEPZBTXEU­­MU-UHF­F­­FAOYSA-N

Mol­e­c­u­lar Formula

C16H18Br2ClN3O3

Mol­e­c­u­lar Weight

495.60

EINECS

241-422-7

Prop­er­ties

Appear­ance

Off-white to white solid

Safe­ty Data

Sym­bol

GHS06, GHS09

Sig­nal Word

Dan­ger

Haz­ard Statements

H300 + H310 + H330-H315-H319-H410

Pre­cau­tion­ary Statements

Miss­ing Phrase – N15.00950417-P260-P280-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338

RIDADR

UN2811 – class 6.1 – PG 1 – EHS – Tox­ic solids, organ­ic, n.o.s., HI : all

WGK Germany

3

RTECS

VA2397066

MSDS Download

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Halofug­i­none Hydro­bro­mide CAS 17395-31-2

Stan­dard

Enter­prise standard

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

98% min

Stor­age

Under the room tem­per­a­ture and away from light

Pro­duc­tiv­i­ty

Hun­dreds of kilo­grams per month

Appli­ca­tion

Halofug­i­none is a coc­cidio­stat used in vet­eri­nary med­i­cine. It is a syn­thet­ic halo­genat­ed deriv­a­tive of febrifug­ine, a nat­ur­al quina­zoli­none alka­loid which can be found in the Chi­nese herb Dichroa febrifu­ga (Chang Shan).Collgard Bio­phar­ma­ceu­ti­cals is devel­op­ing halofug­i­none for the treat­ment of scle­ro­der­ma and it has received orphan drug des­ig­na­tion from the U.S. Food and Drug Admin­is­tra­tion.
Halofug­i­none inhibits the devel­op­ment of T helper 17 cells, immune cells that play an impor­tant role in autoim­mune dis­ease, but it does not affect oth­er kinds of T cells which are involved in nor­mal immune function.Halofuginone there­fore has poten­tial for the treat­ment of autoim­mune dis­or­ders.
Halofug­i­none is also an inhibitor of col­la­gen type I gene expres­sion and as a con­se­quence it may inhib­it tumor cell growth.Halofuginone exerts its effects by act­ing as a high affin­i­ty inhibitor of the enzyme Glu­­tamyl-Pro­­lyl tRNA syn­thetase. Inhi­bi­tion of pro­lyl tRNA charg­ing leads to the accu­mu­la­tion of uncharged pro­lyl tRNAs, which serve as a sig­nal to ini­ti­ate the amino acid star­va­tion response, which in turn exerts anti-inflam­­ma­­to­ry and anti-fibrot­ic effects.

Gen­er­al View of Documents

Halofug­i­none Hydro­bro­mide CAS 17395-31-2 HNMR

Halofug­i­none Hydro­bro­mide CAS 17395-31-2 HPLC

Links

Cam­ing Link

This prod­uct is devel­oped by our RD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd (http://​cam​ing​.com/), focus­ing on API andamp ; Inter­me­di­ate Tech­nol­o­gy and here is the cor­re­spond­ing link in Caming
http://​cam​ing​.com/​h​a​l​o​f​u​g​i​n​o​n​e​-​h​y​d​r​o​b​r​o​m​i​d​e​-​c​a​s​-​1​7​3​9​5​-​3​1​-2/

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you short­ly (Please change screen to hor­i­zon­tal for com­plete brows­ing if you are check­ing Wat­son on your mobile phone).