Halofuginone Hydrobromide CAS 17395-31-2(64924-67-0)

Identification
Properties
Safety Data
Specifications
Links

Identification

CAS Number

17395-31-2
64924-67-0

Molecular Structure

structure of Halofuginone Hydrobromide CAS 17395-31-2

structure of Halofuginone Hydrobromide CAS 17395-31-2

Name

Halofuginone Hydrobromide

Synonyms

(±)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide
(±)-trans-7-Bromo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(±)-
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, hydrobromide (1:1)
7-Brom-6-chlor-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-chinazolinonhydrobromid (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone hydrobromide (1:1)
7-Bromo-6-chloro-3-[3-(3-hydroxy-2-pipéridinyl)-2-oxopropyl]-4(3H)-quinazolinone, bromhydrate (1:1)
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide
4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)acetonyl)-, monohydrobromide
7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-2-oxopropyl)quinazolin-4(3H)-one monohydrobromide
7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3H)-one monohydrobromide
7-bromo-6-chloro-3-[3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;hydrobromide
17395-31-2
64924-67-0
55837-20-2(halofuginone)
1217623-74-9(Halofuginone hydrochloride)

SMILES

c1c2c(cc(c1Cl)Br)ncn(c2=O)CC(=O)CC3C(CCCN3)O.Br

StdInChI

InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H

StdInChIKey

SJUWEPZBTXEUMU-UHFFFAOYSA-N

Molecular Formula

C16H18Br2ClN3O3

Molecular Weight

495.60

EINECS

241-422-7

Properties

Appearance

Off-white to white solid

Safety Data

Symbol

flame-jpgexclamation-mark-jpgGHS06, GHS09

Signal Word

Danger

Hazard Statements

H300 + H310 + H330-H315-H319-H410

Precautionary Statements

Missing Phrase – N15.00950417-P260-P280-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338

RIDADR

UN2811 – class 6.1 – PG 1 – EHS – Toxic solids, organic, n.o.s., HI: all

WGK Germany

3

RTECS

VA2397066

Specifications and Other Information of Our Halofuginone Hydrobromide CAS 17395-31-2

Standard

Enterprise standard

Identification Methods

HNMR, HPLC

Purity

98% min

Storage

Under the room temperature and away from light

Productivity

Hundreds of kilograms per month

Application

Halofuginone is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in the Chinese herb Dichroa febrifuga (Chang Shan).Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and it has received orphan drug designation from the U.S. Food and Drug Administration.
Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.Halofuginone therefore has potential for the treatment of autoimmune disorders.
Halofuginone is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth.Halofuginone exerts its effects by acting as a high affinity inhibitor of the enzyme Glutamyl-Prolyl tRNA synthetase. Inhibition of prolyl tRNA charging leads to the accumulation of uncharged prolyl tRNAs, which serve as a signal to initiate the amino acid starvation response, which in turn exerts anti-inflammatory and anti-fibrotic effects.

General View of Documents

Halofuginone Hydrobromide CAS 17395-31-2 HNMR

Halofuginone Hydrobromide CAS 17395-31-2 HNMR

Halofuginone Hydrobromide CAS 17395-31-2 HPLC

Halofuginone Hydrobromide CAS 17395-31-2 HPLC

Links

Caming Link

This product is developed by our RD company Caming Pharmaceutical Ltd (http://caming.com/), focusing on API andamp; Intermediate Technology and here is the corresponding link in Caming
http://caming.com/halofuginone-hydrobromide-cas-17395-31-2/

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