Structure of PF 07321332 CAS 2628280 40 8 - PF-07321332 CAS 2628280-40-8

Iden­ti­fi­ca­tion

CAS Number

2628280-40-8

Name

PF-07321332

Syn­onyms

(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
PF-07321332 ;
UNII-7R9A5P7H32 ;
GTPL11503 ;
CHEBI:170007 ;
7R9A5P7H32 ;
EX-A5024 ;
PF07321332 ;
PF 07321332 ;
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide ;
(1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide ;
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide ;
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoro-1-oxoethyl)amino]butyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide ;
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxidanylidenepyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide ;
(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-ketopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

SMILES

CC1(C2C1C(N(C2)C(=O)C(C(C)(C)C)NC(=O)C(F)(F)F)C(=O)NC(CC3CCNC3=O)C#N)C

Std­InChI

InChI=1S/C23H32F3N5O4/c1-21(2,3)16(30-20(35)23(24,25)26)19(34)31-10-13-14(22(13,4)5)15(31)18(33)29-12(9-27)8-11-6-7-28-17(11)32/h11-16H,6-8,10H2,1-5H3,(H,28,32)(H,29,33)(H,30,35)/t11-,12-,13-,14-,15-,16+/m0/s1

Std­InChIKey

LIENCH­BZN­N­MNKG-OJFN­HCPVSA-N

Mol­e­c­u­lar Formula

C23H32F3N5O4

Mol­e­c­u­lar Weight

499.5

Prop­er­ties

Appear­ance

White pow­der

Safe­ty Data

RIDADR 

NONH for all modes of transport

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our PF-07321332 CAS 2628280-40-8

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

98% min

Shelf Life

3 years

Stor­age

Store at 2-8℃ for long time

Known Appli­ca­tion

PF-07321332 is an oral­ly bioavail­able 3C-like pro­tease (3CLPRO) inhibitor. This drug is being inves­ti­gat­ed for safe­ty, tol­er­a­bil­i­ty, and phar­ma­co­ki­net­ics before mov­ing on to stud­ies of effi­ca­cy in the treat­ment or pro­phy­lax­is of COVID-19. 3CLPRO is respon­si­ble for cleav­ing polypro­teins 1a and 1ab of SARS-CoV-2. PF-07321332 is an oral COVID-19 antivi­ral clin­i­cal can­di­date. By inhibit­ing the main pro­tease, PF-07321332 pre­vents the virus from cleav­ing long pro­tein chains into the parts it needs to repro­duce itself.

Gen­er­al View of Documents

HNMR of PF 07321332 CAS 2628280 40 8 1 - PF-07321332 CAS 2628280-40-8
HNMR of PF-07321332 CAS 2628280-40-8
LC MS of PF 07321332 CAS 2628280 40 8 - PF-07321332 CAS 2628280-40-8
LC-MS of PF-07321332 CAS 2628280-40-8
LC MS match plot of PF 07321332 CAS 2628280 40 8 - PF-07321332 CAS 2628280-40-8
LC-MS match plot of PF-07321332 CAS 2628280-40-8
HPLC of PF 07321332 CAS 2628280 40 8 - PF-07321332 CAS 2628280-40-8
HPLC of PF-07321332 CAS 2628280-40-8

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd (https://​www​.cam​ing​.com/).

Quick Inquiry

Fill out our inquiry form and one of our experts will be in touch with you shortly.

























    Please prove you are human by select­ing the Car.