Official Full Name
Recombinant Human Betacellulin (rHuBetacellulin)
CAS Number (Or Watson Number for Non-CAS Products)
Amino Acid Sequence DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
) is a member of the EGF
family of cytokines that also includes EGF
, TGF-a, Amphiregulin, HB-EGF
, Epiregulin, Tomoregulin and the Neuregulins. It is expressed in most tissues including kidney, uterus, liver and pancreas. BTC
also presents in body fluids, including serum, milk, and colostrum. At the amino acid sequence level, human mature BTC
protein exhibits 80 % identity with mouse BTC
protein. The protein binds to EGFR
and other EGF
receptor family members and acts as a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF
homologous portion of the Betacellulin protein.
Fully biologically active when compared to standard. The ED50
as determined by a cell proliferation assay using murine Balb/c 3T3
cells is less than 0.05 ng/ml, corresponding to a specific activity of > 2.0 × 107 IU
Sterile filtered white lyophilized (freeze-dried) powder.
Lyophilized from a 0.2 um filtered concentrated solution in PBS
, pH 7.4.
Less than 1 EU
/ug of rHuBTC as determined by LAL
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA
to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
> 98 % by SDS-PAGE
Safety Data Sheet (SDS) Download
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Technical Data Sheet (TDS) Download
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This product is branded by ChemWhat and sold through our website and here is the corresponding link Recombinant Human Betacellulin (rHuBetacellulin) on ChemWhat
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