Beta-Amyloid(1-40), CAS 131438-79-4

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Iden­ti­fi­ca­tion

CAS Number

131438-79-4

Name

Beta-Amyloid(1-40)

Pep­tide sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Syn­onyms

131438-79-4 [RN]
Abeta(1-40)
Abeta40
Amy­loid β-Pep­tide (1-40) (human)
Human β-amy­loid pep­tide (1-40)
β-amy­loid 40
β-amy­loid pro­tein 40
??-Amyloid(1-40) Human
[131438-79-4]
144409-98-3 [RN]
amy­loid ?? pro­tein frag­ment 1-40
Amy­loid ?-Pep­tide (1-40) (human)
amy­loid-β polypep­tide 40
Asp-ala-glu-phe-arg-his-asp-ser-gly-tyr-glu-val-his-his-gln-lys-leu-val-phe-phe-ala-glu-as p-val-gly-ser-asn-lys-gly-ala-ile-ile-gly-leu-met-val-gly-gly-val-val
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
DAE­FGHDS­GFEVRHQK­LVF­FAED­VGSNKGAI­IGLMVG­GVV
DAE­FRHDS­GYEVH­HQK­LVF­FAED­VGSNKGAI­IGLMVG­GVV
https://​www​.ebi​.ac​.uk/​c​h​e​b​i​/​s​e​a​r​c​h​I​d​.​d​o​?​c​h​e​b​i​I​d​=​C​H​E​B​I​:​6​4​646
L-α-aspartyl-L-alanyl-L-α-glu­­tamyl-L-pheny­lalanyl-L-arginyl-L-his­tidyl-L-α-aspartyl-L-seryl­g­ly­­cyl-L-tyro­­syl-L-α-glu­­tamyl-L-valyl-L-his­tidyl-L-his­tidyl-L-glu­t­a­minyl-L-lysyl-L-leucyl-L-valyl-L-pheny­lalanyl-L-pheny­lalanyl-L-alanyl-L-α-glu­­tamyl-L-α-aspartyl-L-valyl­g­ly­­cyl-L-seryl-L-asparaginyl-L-lysyl­g­ly­­cyl-L-alanyl-L-isoleucyl-L-isoleucyl­g­ly­­cyl-L-leucyl-L-methionyl-L-valyl­g­ly­­cyl­g­ly­­cyl-L-valyl-L-valine
MFCD00130509
MFCD00717583
Rat amy­loid-β pep­tide 1-40
β-amy­loid polypep­tide 40
β-amyloid(1-40) human

SMILES

[H]/N=C(\N)/NCCC[C@@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC­CN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC­CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](Cc7ccccc7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N

Std­InChI

InChI=1S/C194H295N53O58S/c1-25-102(19)158(188(299)211-87-143(256)218-124(67-94(3)4)174(285)228-123(62-66-306-24)172(283)241-152(96(7)8)186(297)209-83-140(253)206-84-145(258)240-154(98(11)12)191(302)245-157(101(17)18)193(304)305)247-192(303)159(103(20)26-2)246-162(273)104(21)215-141(254)85-207-164(275)116(47-36-38-63-195)223-181(292)133(77-139(199)252)234-185(296)137(90-249)220-144(257)88-210-187(298)153(97(9)10)242-184(295)135(79-151(269)270)235-170(281)121(56-60-147(261)262)222-161(272)106(23)217-173(284)127(69-107-41-30-27-31-42-107)231-177(288)129(71-109-45-34-29-35-46-109)237-189(300)156(100(15)16)244-183(294)125(68-95(5)6)229-166(277)117(48-37-39-64-196)224-168(279)119(54-58-138(198)251)226-178(289)130(73-111-80-202-91-212-111)233-180(291)132(75-113-82-204-93-214-113)238-190(301)155(99(13)14)243-171(282)122(57-61-148(263)264)227-175(286)126(72-110-50-52-114(250)53-51-110)219-142(255)86-208-165(276)136(89-248)239-182(293)134(78-150(267)268)236-179(290)131(74-112-81-203-92-213-112)232-167(278)118(49-40-65-205-194(200)201)225-176(287)128(70-108-43-32-28-33-44-108)230-169(280)120(55-59-146(259)260)221-160(271)105(22)216-163(274)115(197)76-149(265)266/h27-35,41-46,50-53,80-82,91-106,115-137,152-159,248-250H,25-26,36-40,47-49,54-79,83-90,195-197H2,1-24H3,(H2,198,251)(H2,199,252)(H,202,212)(H,203,213)(H,204,214)(H,206,253)(H,207,275)(H,208,276)(H,209,297)(H,210,298)(H,211,299)(H,215,254)(H,216,274)(H,217,284)(H,218,256)(H,219,255)(H,220,257)(H,221,271)(H,222,272)(H,223,292)(H,224,279)(H,225,287)(H,226,289)(H,227,286)(H,228,285)(H,229,277)(H,230,280)(H,231,288)(H,232,278)(H,233,291)(H,234,296)(H,235,281)(H,236,290)(H,237,300)(H,238,301)(H,239,293)(H,240,258)(H,241,283)(H,242,295)(H,243,282)(H,244,294)(H,245,302)(H,246,273)(H,247,303)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,304,305)(H4,200,201,205)/t102-,103-,104-,105-,106-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-,157-,158-,159-/m0/s1

Std­InChIKey

FEWOU­VR­MG­WFWIH-ILZ­ZQXM­P­SA-N

Mol­e­c­u­lar Formula

C₁₉₄H₂₉₅N₅₃O₅₈S

Mol­e­c­u­lar Weight

4329.80

MDL Number

MFCD00130509

Prop­er­ties

Appear­ance

White pow­der

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR 

NONH for all modes of transport

WGK Germany

3

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Beta-Amyloid(1-40), CAS 131438-79-4

Iden­ti­fi­ca­tion Methods

HNMR, HPLC

Puri­ty

98% min

Absorp­tion coefficient

1280 M-1cm-1 

PI,iso­elec­tric point

pH 5.17 

Net charge at pH 7

-2.7 

Sol­u­bil­i­ty evaluation

Poor water solubility

Tox­i­c­i­ty mech­a­nism of Amy­loid oligomer

1. The effect on oxida­tive stress. Aβ can induce oxida­tive stress, pro­duce a large num­ber of free rad­i­cals, and then pro­duce oxida­tive stress on neurons.
2. Cause Ca2+ dis­or­der. Aβ destroys the K+ chan­nel on the cell mem­brane, caus­ing a large amount of Ca2+ influx.
3. Inter­ac­tion with recep­tors on the cell mem­brane sur­face. Amy­loid oligomers can acti­vate exci­ta­to­ry NMDA2RS recep­tors, caus­ing mito­chon­dr­i­al dis­or­ders and neu­ronal death.
4. Amy­loid in cells is also an impor­tant patho­log­i­cal fea­ture. A large num­ber of oligomers in the cells cause pathol­o­gy. The pro­duc­tion and degra­da­tion of Amy­loid secret­ed by nor­mal cells is rel­a­tive­ly balanced.
5. Break the bal­ance between Bax and Bel-2.

Shelf Life

2 years

Stor­age

Store at -20°C or -80°C for long time, Sealed and away from light

Known Appli­ca­tion

Often used to study Alzheimer’s disease.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Apnoke Sci­en­tif­ic Ltd (http://​www​.apnoke​.com/), and here is the cor­re­spond­ing link http://​www​.apnoke​.com/​b​e​t​a​-​a​m​y​l​o​i​d​1​-​4​0​-​c​a​s​-​1​3​1​4​3​8​-​7​9​-4/

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