Grise­o­ful­vin CAS 126-07-8

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Iden­ti­fi­ca­tion

CAS Number

126-07-8

Name

Grise­o­ful­vin

Syn­onyms

(+)-Grise­o­ful­vin
(1’S-trans)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione
(2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione
(2S,6’R)-7-Chlor-2′,4,6-trimethoxy-6′-methyl-3H,4’H-spiro[1-benzofuran-2,1′-cyclohex[2]en]-3,4′-dion [Ger­man]
(2S,6’R)-7-Chloro-2′,4,6-trimethoxy-6′-methyl-3H,4’H-spiro[1-benzofuran-2,1′-cyclohex[2]ene]-3,4′-dione [ACD/IUPAC Name]
(2S,6’R)-7-Chloro-2′,4,6-triméthoxy-6′-méthyl-3H,4’H-spiro[1-benzofurane-2,1′-cyclohex[2]ène]-3,4′-dione [French]
126-07-8 [RN]
204-767-4 [EINECS]
875
95226 [Beil­stein]
amu­dane
Curl­ing fac­tor
Ful­cin [Trade name]
Ful­vicin [Trade name]
Gri­ful­vin [Trade name]
Gris­actin [Trade name]
Grise­o­ful­vin [BAN] [INN] [JAN] [USAN] [Wiki]
Grise­o­ful­vin Per­me­abil­i­ty Diam­e­ter
grise­o­ful­v­ina [Span­ish] [INN]
grise­o­ful­vine [French] [INN]
griséo­ful­vine [French] [INN]
grise­o­ful­v­inum [Latin] [INN]
Griso­vin [Trade name]
Grize­o­ful­vin [Trade name]
Lam­oryl [Trade name]
Liku­den [Trade name]
Likun­den [Trade name]
MFCD00082343 [MDL num­ber]
Poly­gris [Trade name]
Pon­cyl [Trade name]
Spiro[benzofuran-2(3H),1′-cyclohex[2]ene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (2S,6’R)- [ACD/​Index Name]
Spiro­ful­vin [Trade name]
Sporo­statin [Trade name]
WG9800000
гризеофульвин [Russ­ian] [INN]
غريزيوفولفين [Ara­bic] [INN]
灰黄霉素 [Chi­nese] [INN]
Ful­vicin U/F
Griso­vin FP
Sporo­statin xan
Xuan­jing
(+)-grise­o­ful­vin ; Amu­dane ; Grise­o­ful­vin, micro­crys­talline ; Grise­o­ful­vin, ultra­mi­cro­size ; Grise­o­ful­v­ina ; Grise­o­ful­vine ; Grise­o­ful­v­inum
(+)-grise­o­ful­vin ; Amu­dane ; Grise­o­ful­v­ina ; Grise­o­ful­vine ; Grise­o­ful­v­inum
(1’S,6’R)-7-chloro-2′,4,6-trimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohex[2]ene]-3,4′-dione
(1’S,6’R)-7-Chloro-2′,4,6-trimethoxy-6′-methyl-spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione
(1’S-trans)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2(3H),1′-(2)cyclohexene)-3,4′-dione
(2S)-trans-7-Chloro-2?,4,6-trimethoxy-6?-methylspiro(benzofuran-2[3H,1?-[2]cyclohexene)-3,4?-dione
(2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione
(2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione
(2S,5’R)-7-chloro-3′,4,6-trimethoxy-5′-methylspiro[1-benzofuran-2,4′-cyclohex-2-ene]-1′,3-dione
(2S,5’R)-7-chloro-3′,4,6-trimethoxy-5′-methyl-spiro[1-benzofuran-2,4′-cyclohex-2-ene]-1′,3-dione
(2S,5’R)-7-chloro-3′,4,6-trimethoxy-5′-methylspiro[1-benzofuran-2,4′-cyclohexane]-1′,3-dione
(2S,5’R)-7-chloro-3′,4,6-trimethoxy-5′-methylspiro[benzofuran-2,4′-cyclohex-2-ene]-1′,3-dione
(2S,5’R)-7-chloro-3′,4,6-trimethoxy-5′-methyl-spiro[benzofuran-2,4′-cyclohex-2-ene]-1′,3-dione
(2S,5’R)-7-chloro-3′,4,6-trimethoxy-5′-methyl-spiro[benzofuran-2,4′-cyclohex-2-ene]-1′,3-quinone
(2S,6’R)-7-Ch
(2S,6’R)-7-chloro-2′,4,6-trimethoxy-6′-methyl-3H-spiro[1-benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione
(2S,6’R)-7-chloro-2′,4,6-trimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione
(2S-trans)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2(3H),1′-(2)cyclohexene)-3,4′-dione
[126-07-8]
2884-22-2 [RN]
5-18-05-00150 [Beil­stein]
5-18-05-00150 (Beil­stein Hand­book Ref­er­ence) [Beil­stein]
78739-00-1 [RN]
7-Chloro-2′,4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′,- [2]cyclohexene]-3,4′-dione
7-chloro-2′,4,6-trimethoxy-6’R-methyl-spiro[benzofuran-2(3H)-1’S-[2]cyclohexene]-3,4′-dione
7-Chloro-2′,4,6-trimethoxy-6’β-methylspiro(benzofuran-2(3H),1′-(2)cyclohexene)-3,4′-dione
7-chloro-3′,4,6-trimethoxy-5′-methylspiro[benzofuran-2,4′-cyclohexane]-1′,3-dione
7-chloro-4,6,2′-trimethoxy-6′-methylgris-2′-en-3,4′-dione
7-Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1′-(2′-methoxy-6′-methylcyclohex-2′-en-4′-one)
ACon0_​000953
ACon1_​001843
Amudane;Grifulvin V;Gris-PEG
BB_NC-0702
biogrisin-fp
BPBio1_​000299
BSPBio_​000271
BSPBio_​001621
C17H17ClO6
Criv­icin
Criv­icin (Trade name)
Criv­icin ; Ful­cin ; Ful­vicin ; Gri­ful­vin ; Gri­ful­vin V ; Gris­actin ; Gri­­son-250 ; Griso­vin ; Lam­oryl ; Liku­den ; Pon­cyl ; S-Ful­vin ; Spiro­ful­vin ; Sporo­statin
del­mo­ful­v­ina
EINECS 204-767-4
Ful­cine
ful­vi­can gris­actin
FUL­VICIN P/G
ful­vicin UF
FUL­VICIN-U/F
ful­v­ina
Ful­vinil
ful­vis­tatin
fun­givin
gre­osin
gres­feed
gricin
Gri­fulin
Gri­ful­vin V (Trade name)
grisco­ful­vin
grise­fu­line
griseo
Grise­o­ful­vin, EP grade
Grise­o­ful­vin, ultra­mi­cro­size
griseofulvin;fulcin
Griseofulvin|Amudane
Grise­o­ful­v­ina
Grise­o­ful­vine
grise­o­­ful­vin-forte
Griseomix
Grisetin
Griso­ful­vin
Gri­­son-250
Gri­­son-250 (Trade name)
Gri­vate
Gry­sio
guservin
IDI1_000154
Idi­ful­vin
LMPK02000019
MEGxm0_​000184
mur­ful­vin
NCGC00091120-02
NCGC00091120-03
neo-ful­cin
Noro­ful­vin
Phar­­makon1600-00200046
Prestwick3_​000226
QA-6115
S-Ful­vin
S-Ful­vin (Trade name)
SPECTRUM200046
Spectrum5_​000648
Spiro(benzofuran-2(3H),1′-(2)cyclohexene)-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (1’S-trans)-
Spiro(benzofuran-2(3H),1′-(2)cyclohexene)-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (2S-trans)-
ULTRA­­­GRIS-165
ULTRA­­­GRIS-330

SMILES

C[C@@H]1CC(=O)C=C([C@]12C(=O)c3c(cc(c(c3O2)Cl)OC)OC)OC

Std­InChI

InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1

Std­InChIKey

DDUHZ­­TY­CFQRHIY-RBHX­EPJQSA-N

Mol­e­c­u­lar Formula

C₁₇H₁₇ClO₆

Mol­e­c­u­lar Weight

352.766

EINECS

204-767-4

Beil­stein Reg­istry Number

95226

MDL Number

MFCD00082343

Prop­er­ties

Appear­ance

A white or yel­low­ish-white, microfine powder.

Melt­ing Point

217℃~224℃

Safe­ty Data

Sym­bol

GHS07, GHS08

Sig­nal Word

Dan­ger

Haz­ard statements

H317-H351-H360

Pre­cau­tion­ary Statements

P201-P280-P308 + P313

Per­son­al Pro­tec­tive Equipment

Eye­shields, Faceshields, Gloves, res­pi­ra­tor car­tridge type N100 (US), type P1 (EN143) res­pi­ra­tor fil­ter, type P3 (EN 143) res­pi­ra­tor cartridges

RIDADR 

NONH for all modes of transport

WGK Germany

3

RTECS 

WG9800000

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Grise­o­ful­vin CAS 126-07-8

Iden­ti­fi­ca­tion Methods

HPLC ;GC

Iden­ti­fi­ca­tion

The infrared absorbance spec­trum is con­cor­dant with the ref­er­ence spectrum;A wine-red col­or is produced

Sol­u­bil­i­ty

Prac­ti­cal­ly insol­u­ble in water, freely sol­u­ble in dimethyl­for­mamide and in tetra­chloroethane, slight­ly sol­u­ble in anhy­drous ethanol and in methanol

Par­ti­cle Size

The par­ti­cles of which are gen­er­al­ly up to 5um in max. dimen­sion ; Larg­er par­ti­cles which may occa­sion­al­ly exceed 30um

Appear­ance Of Solution

The solu­tion is clear and not more intense­ly coloured than ref­er­ence solu­tion Y4.

Acid­i­ty

Not more than 1.0ml of 0.02M sodi­um hydrox­ide is required

Assay (Dried Sub­stance)

97%~102%

Spe­cif­ic Opti­cal Rotation

+352°~+364°

Relat­ed Sub­stances (GC)

-Cl : <0.60 ; -H : <0.15

Heavy Met­als

≤20ppm

Sub­stance Sol­u­ble In Light Petroleum

≤0.2%

Loss on Drying

≤1.0%

Sul­fat­ed Ash

≤0.2%

Resid­ual Solvents

Ethanol : ≤0.5%

Ace­tone : ≤0.5%

Dichloromethane : ≤0.06%

Abnor­mal Toxicity

Five mice orals, none of the mice dies With­in 48h

Shelf Life

4 years

Stor­age

Under room tem­per­a­ture away from light

Known Appli­ca­tion

Used for tinea capi­tis, ony­chomy­co­sis, tinea capi­tis, tinea pedis and tinea capi­tis caused by sen­si­tive fungi.

Links

This prod­uct is devel­oped by our R&D com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​g​r​i​s​e​o​f​u​l​v​i​n​-​c​a​s​-​1​2​6​-​0​7​-8/

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