Structure of Bimatoprost CAS 155206 00 1 - Bimatoprost CAS 155206-00-1

Iden­ti­fi­ca­tion
Prop­er­ties
Safe­ty Data
Spec­i­fi­ca­tions andamp ; Oth­er Information
Links

Iden­ti­fi­ca­tion

CAS Number

155206-00-1

Name

Bimato­prost

Syn­onyms

(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamid [Ger­man] [ACD/IUPAC Name]
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl}-N-ethyl-5-heptenamide [ACD/IUPAC Name]
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phényl-1-pentén-1-yl]cyclopentyl}-N-éthyl-5-hepténamide [French] [ACD/IUPAC Name]
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl}-N-ethylhept-5-enamide
5-Hep­­te­­namide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)- [ACD/​Index Name]
bimato­prost [French] [INN]
bimato­prost [Span­ish] [INN]
Bimato­prost [USAN] [Wiki]
bimato­pros­tum [Latin] [INN]
Lumi­gan [Trade name]
биматопрост [Russ­ian] [INN]
بيماتوبروست [Ara­bic] [INN]
贝美前列素 [Chi­nese] [INN]
(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide
(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-5-heptenamide
(Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenyl-pent-1-enyl]cyclopentyl]-N-ethyl-hept-5-enamide
[155206-00-1]
155206-00-1 [RN]
267244-98-4 [RN]
5-Hep­­te­­namide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (5Z)-
5-Hep­­te­­namide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1α(Z),2β(1E,3S*),3α,5α))-
AGN 192024|LS-181817|Lumi­gan®
Lumi­gan (TN)
Lumi­gan®
Lumi­gan ; Latisse ; AGN 192024 ; bimato­pros­tum ; Lumi­gan (TN); AC1NSJUW ; AGN-192024 ; UNII-QXS94885MZ
MFCD03411999 [MDL num­ber]
UNII-QXS94885MZ

Mol­e­c­u­lar Structure

Structure of Bimatoprost CAS 155206 00 1 - Bimatoprost CAS 155206-00-1

Struc­ture of Bimato­prost CAS 155206-00-1

SMILES

CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCc2ccccc2)O)O)O

Std­InChI

InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1

Std­InChIKey

AQOKCD­NY­W­BID­ND-FTOWTWD­K­SA-N

Mol­e­c­u­lar Formula

C25H37NO4

Mol­e­c­u­lar Weight

415.57

Prop­er­ties

Appear­ance

White pow­der ; very sol­u­ble in eth­yl alco­hol and methyl alco­hol and slight­ly sol­u­ble in water.

Safe­ty Data

Per­son­al Pro­tec­tive Equipment

Eye­shields, Gloves, type N95 (US), type P1 (EN143) res­pi­ra­tor filter

RIDADR

NONH for all modes of transport

WGK Germany

3

MSDS

MSDS of Bimato­prost CAS 155206-00-1

Spec­i­fi­ca­tions and Oth­er Infor­ma­tion of Our Bimato­prost CAS 155206-00-1

Stan­dard

Enter­prise standard

Cer­tifi­cate

GMP

Iden­ti­fi­ca­tion Methods

HNMR/HPLC

Puri­ty

99.5% min

Spe­cif­ic Opti­cal Rotation

+33.0-+37.0°

Heavy Met­als

10ppmmax

Residue on Ignition

0.1%max

Sin­gle Impurity

0.1%max

Total Impu­ri­ties

0.5%max

Descrip­tion

Bimato­prostoph­thalmic solu­tion 0.01% and 0.03% is a syn­thet­ic prostamide ana­log with ocu­lar hypoten­sive activ­i­ty ; is aclear, isotonic,colorless ster­ile oph­thalmic solu­tion with an osmo­lal­i­ty­of approx­i­mate­ly 290 mOsmol/​kg.

Adding pro­por­tion for reference

Bimato­prostoph­thalmic solu­tion : 0.01% con­tains Active :
bimato­prost 0.1 mg/​mL ;
Preservative:benzalkonium chlo­ride 0.2mg/ml ;
Inac­tives : sodi­um chlo­ride ; sodi­um phosphatedibasic;citric acid;and puri­fied water.
Sodi­um hydrox­ide and/​or hydrochlo­ric acid may be added to adjust pH. The pH dur­ing its shelf life ranges from 6.8-7.8.

Bimato­prostoph­thalmic solu­tion : 0.03% con­tains Active :
bimato­prost : 0.3 mg/​mL ;
Preservative:benzalkonium chlo­ride : 0.05 mg/​mL ;
Inac­tives : sodi­um chlo­ride ; sodi­um phosphate,dibasic ; cit­ric acid;and puri­fied water.
Sodi­um hydrox­ide and/​or hydrochlo­ric acid may be added to adjust pH. The pH dur­ing its shelf life ranges­from 6.8-7.8.

Stor­age

Store at the 2-8℃

Appli­ca­tion

Bimato­prost is a prostaglandin ana­log used top­i­cal­ly (as eye drops) to con­trol the pro­gres­sion of glau­co­ma and in the man­age­ment of ocu­lar hyper­ten­sion. It reduces intraoc­u­lar pres­sure (IOP) by increas­ing the out­flow of aque­ous flu­id from the eyes. It has also been used and pre­scribed off-label to length­en eyelashes.

Gen­er­al View of Documents

Normal Phase HPLC of Bimatoprost CAS 155206 00 1 - Bimatoprost CAS 155206-00-1

Nor­mal Phase HPLC of Bimato­prost CAS 155206-00-1

Reverse Phase HPLC of Bimatoprost CAS 155206 00 1 - Bimatoprost CAS 155206-00-1

Reverse Phase HPLC of Bimato­prost CAS 155206-00-1

Links

This prod­uct is devel­oped by our RD com­pa­ny Cam­ing Phar­ma­ceu­ti­cal Ltd(http://​www​.cam​ing​.com/), and here is the cor­re­spond­ing linkhttp://​www​.cam​ing​.com/​b​i​m​a​t​o​p​r​o​s​t​-​c​a​s​-​1​5​5​2​0​6​-​0​0​-1/

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