R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8

Identification
Properties
Safety Data
Specifications & Other Information
Links

Identification

CAS Number

14358-90-8

Name

R-alpha-Lipoic acid tromethamine salt

Synonyms

1,2-Dithiolane-3-pentanoic acid, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) [ACD/Index Name]
14358-90-8 [RN]
238-329-9 [EINECS]
5-(1,2-Dithiolan-3-yl)pentanoic acid – 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1) [ACD/IUPAC Name]
5-(1,2-Dithiolan-3-yl)pentansäure –2-amino-2-(hydroxymethyl)-1,3-propandiol (1:1) [German] [ACD/IUPAC Name]
Acide 5-(1,2-dithiolan-3-yl)pentanoïque – 2-amino-2-(hydroxyméthyl)-1,3-propanediol (1:1) [French] [ACD/IUPAC Name]
UNII:V8276EBZ06
1,2-dithiolane-3-valeric acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
2-amino-2-(hydroxymethyl)propane-1,3-diol; 5-(3-dithiolanyl)pentanoic acid
2-azanyl-2-(hydroxymethyl)propane-1,3-diol
5-(3-dithiolanyl)pentanoic acid
6,8-THIOCTIC ACID
R-α-Lipoic acid tromethamine salt
R-α-Lipoic acidtromethaminesalt
THIOCTATE TROMETAMOL
tris buffer

Molecular Structure

Structure of R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8

Structure of R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8

SMILES

C1CSSC1CCCCC(=O)O.C(C(CO)(CO)N)O

StdInChI

InChI=1S/C8H14O2S2.C4H11NO3/c9-8(10)4-2-1-3-7-5-6-11-12-7;5-4(1-6,2-7)3-8/h7H,1-6H2,(H,9,10);6-8H,1-3,5H2

StdInChIKey

CCTREOMTIFSZAU-UHFFFAOYSA-N

Molecular Formula

C12H25NO5S2

Molecular Weight

327.46

Properties

Appearance

Off-white or pale yellow crystal powder

Melting Point

115~120℃

Safety Data

WGK Germany

3

Specifications and Other Information of Our R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8

Standard

Enterprise standard

Identification Methods

HNMR,HPLC

Purity

99%min

Optical purity

99%min

Specific Optical Rotation

+67℃~+77℃

Heavy Metals

20ppm max

Loss on Drying

0.5%max

Residue on Ignition

0.2%max

Package

According to customer requirements to packaging

Storage

Under the room temperature and away from light

Application

Lipoic acid (LA), also known as alpha lipoic acid (ALA) and thioctic acid is an organosulfur compound which is widely used as a dietary supplement in some countries marketed as an antioxidant and is available as a pharmaceutical drug in other countries.

Alpha-Lipoic Acid bulk material available today is (R/S) or (+/-) Alpha Lipoic Acid (ALA), meaning it contains a 50/50 mixture of (R-Lipoic) and unnatural (S-Lipoic) Lipoic Acid. The S-Lipoic Acid form, which is not found anywhere in nature, is a byproduct of chemical synthesis. Research indicates that not only does the human body have difficulty absorbing this unnatural version, it may inhibit the most essential properties of the R-Lipoic Acid form!

The “R” form (R Lipoic) is considered the “eutomer” (the biologically superior form) of Alpha Lipoic Acid, since it is identical to that produced by the body. Research indicates R-Lipoic Acid is responsible for most of the beneficial effects attributed to ALA.

While R Lipoic Acid is the obvious choice over Alpha Lipoic Acid, pure R-Lipoic Acid in its “free-acid” form has two major drawbacks: stability and bioavailability. Without special processing, R-Lipoic Acid is highly unstable and difficult to absorb. In fact, pharmacokinetic data reveal that while Alpha Lipoic Acid has a very low absorption rate, unstabilized R-Lipoic Acid is absorbed even worse!

As one of the largest fine chemical developers globally, Watson solved the stability issue by bringing in two other derivates R(+)-Alpha Lipoic Acid Sodium CAS 176110-81-9 and R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8, being one of the world’s largest purveyor of commercially produced stabilized R-Lipoic Acid materials.

You know check here to know more about our two products,

R (+)-Alpha Lipoic Acid Sodium CAS 176110-81-9https://www.watson-int.com/r-alpha-lipoic-acid-sodium-cas-176110-81-9/

R-(+)-alpha-Lipoic acid CAS 1200-22-2: https://www.watson-int.com/r-alpha-lipoic-acid-cas-1200-22-2/

General View of Documents

R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8 HNMR

R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8 HNMR

R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8 HPLC

R-alpha-Lipoic acid tromethamine salt CAS 14358-90-8 HPLC

Links

This product is developed by our R&D company Ulcho Biochemical Ltd(http://www.ulcho.com/), and here is the corresponding linkhttp://www.ulcho.com/r-alpha-lipoic-acid-tromethamine-salt-cas-14358-90-8/

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Disclaimer

This product is for research and development purpose only which may not be used directly as drugs, food, cosmetics or for any other non-R&D purpose. It may be toxic or hazardous, and should be handled only by qualified individuals trained in laboratory procedures. The buyer will be responsible to warn and inform any person that may be in contact with the product of the potential risks and hazards, as well as to ensure that purchase, use and disposal of the product comply with local laws and regulations.