Travoprost CAS 157283-68-6

Travoprost CAS 157283-68-6

Identification
Properties
Safety Data
Specifications andamp; Other Information
Links

Identification

CAS Number

157283-68-6

Name

Travoprost

Synonyms

(+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2
15(S)-FLU-IPR
15(S)-FLUPROSTENOL ISOPROPYL ESTER
(+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
9ALPHA,11ALPHA,15S-TRIHYDROXY-16(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
(+)-FLUPROSTENOL ISOPROPYL ESTER
FLUPROSTENOL ISOPROPYL ESTER
FLU-IPR
1-methylethyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
Travatan
Travatan Z

Molecular Structure

structure of Travoprost CAS 157283-68-6

SMILES

FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)CC=C/CCCC(=O)OC(C)C)ccc2

StdInChI

InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1

StdInChIKey

MKPLKVHSHYCHOC-AHTXBMBWSA-N

Molecular Formula

C26H35F3O6

Molecular Weight

500.5477

Properties

Appearance

Light yellow to almost colourless oil

Flash Point

307.5°C

Boiling Point

584.8°C at 760 mmHg

Density

1.245g/ml

Refractive Index

1.547

Safety Data

Symbol

flame-jpgexclamation-mark-jpgGHS02, GHS07

Risk Statements (Europe)

11-36/37/38

Safety Statements (Europe)

16-26-36

Specifications and Other Information of Our Travoprost CAS 157283-68-6

Standard

USP34

Identification Methods

HPLC, TLC

Assay

96.0%-102%

Solubility

Soluble in chloroform,ethyl acetate, acetone, practically insoluble in water

Specific Rotation

+52°~+58°,(C=1 CH2Cl2)

Water

≤1.0%

Related Compounds

Epoxide derivative ≤0.40%
15-epi Diastereomer ≤0.1%
5,6-trans Isomer ≤3.5%
15-Keto derivative ≤0.3%
Any other impurities ≤0.1%
Total other impurity ≤1.0%

Related Solvents

Isopropanol ≤0.5%
Ethyl acetate ≤0.25%
n-Hexane ≤0.029%
Ethanol ≤0.5%

Known Application

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure.

Package

Plastic bag inside and paper drum outside.

Productivity

kg scale/month

Storage

Glass bottle, 2-8°C for shipment and 0 ℃ for long time storage

General View of Documents

Travoprost-CAS-157283-68-6-NMR1

Travoprost-CAS-157283-68-6-NMR1

Travoprost-CAS-157283-68-6-NMR2

Travoprost-CAS-157283-68-6-NMR2

Travoprost-CAS-157283-68-6-NMR3

Travoprost-CAS-157283-68-6-NMR3

Available Impurities

Impurity 1
Name: Epoxide Derivative
Chemical Name: (5Z)-(9S,11R,15S)-9,11,15-Trihydroxy-13,14-epoxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)
Structure-of-1314-Epoxy-derivative-of-Travoprost
Impurity 2
Name: 15-epi Diastereomer
Chemical Name: (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure-of-15-epi-Diastereomer

Structure-of-15-epi-Diastereomer

Impurity 3
Name: 5,6-trans Isomer
Chemical Name: (5E,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure-of-56-trans-Isomer

Structure-of-56-trans-Isomer

Impurity 4
Name: 15-keto derivative
Full Name: (5Z,13E)-(9S,11R)-9,11-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester
Appearance: Yellow oil
CAS: 404830-45-1
Identification: HNMR,MS,HPLC
Purity: 98%min(HPLC)

Structure-of-15-keto-Travoprost-CAS-404830-45-1

Structure-of-15-keto-Travoprost-CAS-404830-45-1

Links

This product is developed by our RD company Caming Pharmaceutical Ltd(http://www.caming.com/), and here is the corresponding linkhttp://caming.com/travoprost-cas-157283-68-6-2/

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